Protein FGF family* map

Identifiers
fibroblast growth factor 1 (acidic)
HUGO:FGF1, HGNC:3665, ENTREZ:2246, GENECARDS:GC05M141953, UNIPROT:P05230
fibroblast growth factor 2 (basic)
FGFB
HUGO:FGF2 HGNC:3676 ENTREZ:2247 UNIPROT:P09038
fibroblast growth factor 3
"fibroblast growth factor 3 (murine mammary tumor virus integration site (v-int-2) oncogene homolog)",
INT2, HBGF-3, "INT-2 proto-oncogene protein", "murine mammary tumor virus integration site 2, mouse",
HUGO:FGF3 HGNC:3681 ENTREZ:2248 UNIPROT:P11487
fibroblast growth factor 4
"heparin secretory transforming protein 1", HSTF1
HUGO:FGF4 HGNC:3682 ENTREZ:2249 UNIPROT:P08620
fibroblast growth factor 6
HUGO:FGF6 HGNC:3684 ENTREZ:2251 UNIPROT:P10767
fibroblast growth factor 7
HUGO:FGF7 HGNC:3685 ENTREZ:2252 UNIPROT:P21781
fibroblast growth factor 8 (androgen-induced)
HUGO:FGF8 HGNC:3686 ENTREZ:2253 UNIPROT:P55075
"fibroblast growth factor 9 (glia-activating factor)"
HUGO:FGF9 HGNC:3687 ENTREZ:2254 UNIPROT:P31371
fibroblast growth factor 10
HUGO:FGF10 HGNC:3666 ENTREZ:2255 UNIPROT:O15520
fibroblast growth factor 16
HUGO:FGF16 HGNC:3672 ENTREZ:8823 UNIPROT:O43320
fibroblast growth factor 19
HUGO:FGF19 HGNC:3675 ENTREZ:9965 UNIPROT:O95750

Maps_Modules
HMC:ACTIVATING_INVASION_AND_METASTASIS
 EMT Senescence  map  / EMT_REGULATORS  map
 EMT Senescence  map  / ECM  map

References
PMID:14517404
Fibroblast growth factor FGF1, a prototypic member of the FGF family, has the ability to stimulate angiogenesis in an in vivo model of angiogenesis.
Eggs received secreted FGF1 showed a significant increase in vascularization when compared to eggs received vector alone plasmids.
PMID:16272825
This FGF1-mediated angiogenesis involves in the PI3K/AKT pathway.
Blocked PI3K pathway via LY294002 in FGF1-transfected CAMs (chicken chorio- allantoic membrane) signifi cantly inhibited angiogenesis
PMID:16682805
Both activity and mRNA expression levels of the Ets1 molecule were increased in response to FGF1 overexpression
Ets-1 activation is a requisite for FGF1-mediated angiogenesis in vivo.

Modifications:
In compartment: Extracellular space
  1. FGF family*@Extracellular space map
Participates in complexes:
In compartment: Cytosol
  1. FGF family*|​hm2:​FGFR family*:​Heparin|​hm2@Cytosol map
Participates in reactions:
As Reactant or Product:
  1. FGF family*@Extracellular space map → map FGFR1-ligands*@Extracellular space map
  2. FGF family*@Extracellular space map → map FGFR2-ligands*@Extracellular space map
  3. FGF family*@Extracellular space map → map FGFR3-ligands*@Extracellular space map
  4. FGF family*@Extracellular space map → map FGFR4-ligands*@Extracellular space map
  5. FGFR family*@Cytosol map + FGF family*@Extracellular space map + Heparin@Extracellular space map → map FGF family*|​hm2:​FGFR family*:​Heparin|​hm2@Cytosol map
  6. FGF family*|​hm2:​FGFR family*:​Heparin|​hm2@Cytosol map → map FGFR2|​hm2|​active@Cytosol map
  7. FGF family*|​hm2:​FGFR family*:​Heparin|​hm2@Cytosol map → map FGFR1|​hm2|​active@Cytosol map
  8. FGF family*|​hm2:​FGFR family*:​Heparin|​hm2@Cytosol map → map FGFR3|​hm2|​active@Cytosol map
  9. FGF family*|​hm2:​FGFR family*:​Heparin|​hm2@Cytosol map → map FGFR4|​hm2|​active@Cytosol map
As Catalyser: