Complex CDK2:CyclinE*
Complex composition:
- CDK2
- CyclinE*
CDK2|Y14/15_pho:CyclinE*@Nucleus
Identifiers
NAME:CDK2:CyclinE*
Maps_Modules
HMC:SUSTAINING_PROLIFERATIVE_SIGNALLING
Cell Cycle DNA Repair
/ G1_CC_PHASE
(CDK2|T160_pho:CyclinE*)|active@Nucleus
Identifiers
NAME:CDK2:CyclinE*
Maps_Modules
HMC:SUSTAINING_PROLIFERATIVE_SIGNALLING
Cell Cycle DNA Repair
/ G1_CC_PHASE
References
ce_re115( Cell Cycle DNA Repair
):
PMID:16581787,
For inhibition of S-checkpoint by ATM:
PMID:15175241
Inhibition of Sphase by MRE complex:
PMID:17713585
By CycE*/CDK2: G1/S transition
By CycD*/CDK2/CIp/KIP: checkpoint G1/S
ce_re355( Cell Cycle DNA Repair
):
For role of TIM1*/TIPIN in S-phase checkpoint, replication arrest, stalled replication forks stabilisation and DNA repair during S-phase:
PMID:17102137, PMID:17116885, PMID:17296725, PMID:19793801, PMID:17582221
ce_re415:( Cell Cycle DNA Repair
) PMID:17038621, PMID:15677884
CDK2|T160_pho|Y14/15_pho:CyclinE*@Nucleus
Identifiers
NAME:CDK2:CyclinE*
Maps_Modules
HMC:SUSTAINING_PROLIFERATIVE_SIGNALLING
Cell Cycle DNA Repair
/ G1_CC_PHASE
Modifications:
Participates in complexes:
In compartment: Nucleus
- CDK2|Y14/15_pho:CyclinE*@Nucleus
- (CDK2|T160_pho:CyclinE*)|active@Nucleus
- CDK2|T160_pho|Y14/15_pho:CyclinE*@Nucleus
Participates in reactions:
As Reactant or Product:- ce_s3119 →
CDK2|Y14/15_pho:CyclinE*@Nucleus
- CDK2|Y14/15_pho:CyclinE*@Nucleus
→
CDK2|T160_pho|Y14/15_pho:CyclinE*@Nucleus
- CDK2|T160_pho|Y14/15_pho:CyclinE*@Nucleus
→
(CDK2|T160_pho:CyclinE*)|active@Nucleus
As Catalyser:- G1 phase@Nucleus
→
S phase@Nucleus
- E2F1:RB1@Nucleus
→
E2F1:RB1|pho@Nucleus
- E2F4_5*:p107*@Nucleus
→
E2F4_5*:p107*|pho@Nucleus
- CIP1_KIP1*@Nucleus
→
degraded
- ORC4*@Nucleus
+ ORC5*@Nucleus
+ ORC6*@Nucleus
+ ORC3*@Nucleus
+ ORC2*@Nucleus
+ ORC1*@Nucleus
→
ORC1*:ORC2*:ORC3*:ORC4*:ORC5*:ORC6*@Nucleus
- MCM5@Nucleus
+ MCM6@Nucleus
+ MCM7@Nucleus
+ MCM2@Nucleus
+ MCM3@Nucleus
+ MCM4@Nucleus
→
MCM2:MCM3:MCM4:MCM5:MCM6:MCM7@Nucleus
- ORC1*:ORC2*:ORC3*:ORC4*:ORC5*:ORC6*@Nucleus
+ MCM2:MCM3:MCM4:MCM5:MCM6:MCM7@Nucleus
+ CDT1@Nucleus
+ CDC6@Nucleus
+ CDC45@Nucleus
+ POLA*@Nucleus
+ PRIM*@Nucleus
+ RPA1@Nucleus
+ RPA2@Nucleus
+ RPA3@Nucleus
→
CDC45:CDC6:CDT1:MCM2:MCM3:MCM4:MCM5:MCM6:MCM7:ORC1*:ORC2*:ORC3*:ORC4*:ORC5*:ORC6*:POLA*:PRIM*@Nucleus
- FOXO*@Nucleus
→
FOXO*|unk@Nucleus