PP2A*

Protein PP2A*

Identifiers
HUGO:PPP2CA HUGO:PPP2CB
protein phosphatase 2A activator, regulatory subunit 4
HUGO:PPP2R4, HGNC:9308, ENTREZ:5524, UNIPROT:Q9NNZ7
protein phosphatase 2 (formerly 2A), catalytic subunit, alpha isoform
HUGO:PPP2CA, HGNC:9299, ENTREZ:5515, UNIPROT:P67775
protein phosphatase 2, regulatory subunit B', gamma isoform
HUGO:PPP2R5C , HGNC:9311, ENTREZ:5527, UNIPROT:Q13362
protein phosphatase 2, regulatory subunit B', delta isoform
HUGO:PPP2R5D , HGNC:9312, ENTREZ:5528, UNIPROT:Q14738
protein phosphatase 2 (formerly 2A), regulatory subunit B, beta isoform
HUGO:PPP2R2B, HGNC:9305, ENTREZ:5521, UNIPROT:Q00005
protein phosphatase 2, regulatory subunit B', alpha isoform
HUGO:PPP2R5A , HGNC:9309, ENTREZ:5525, UNIPROT:Q15172
protein phosphatase 2 (formerly 2A), regulatory subunit B, alpha isoform
HUGO:PPP2R2A , HGNC:9304, ENTREZ:5520, UNIPROT:P63151
protein phosphatase 2, regulatory subunit B', epsilon isoform
HUGO:PPP2R5E , HGNC:9313, ENTREZ:5529, UNIPROT:Q16537
protein phosphatase 2 (formerly 2A), regulatory subunit A, beta isoform
HUGO:PPP2R1B , HGNC:9303, ENTREZ:5519, UNIPROT:P30154
protein phosphatase 2 (formerly 2A), regulatory subunit A, alpha isoform
HUGO:PPP2R1A, HGNC:9302, ENTREZ:5518, UNIPROT:P30153
protein phosphatase 2 (formerly 2A), regulatory subunit B, gamma isoform
HUGO:PPP2R2C, HGNC:9306, ENTREZ:5522, UNIPROT:Q9Y2T4
protein phosphatase 2, regulatory subunit B', beta isoform
HUGO:PPP2R5B , HGNC:9310, ENTREZ:5526, UNIPROT:Q15173
protein phosphatase 2 (formerly 2A), regulatory subunit B'', alpha
HUGO:PPP2R3A , HGNC:9307, ENTREZ:5523, UNIPROT:Q06190
protein phosphatase 2 (formerly 2A), catalytic subunit, beta isoform
HUGO:PPP2CB , HGNC:9300, ENTREZ:5516, UNIPROT:P62714
HUGO:PPP2R2D , HGNC:23732, ENTREZ:55844, UNIPROT:Q66LE6
protein phosphatase 2 (formerly 2A), regulatory subunit B'', beta
HUGO:PPP2R3B , HGNC:13417, ENTREZ:28227, UNIPROT:Q9Y5P8
protein phosphatase 2, catalytic subunit, beta isozyme
protein phosphatase 2, regulatory subunit A, alpha

Maps_Modules
HMC:AVOIDING_IMMUNE_DESTRUCTION
Adaptive Immune Response / INHIBITING_CHECKPOINTS
Adaptive Immune Response / TCR_SIGNALING
Adaptive Immune Response / SMAC
HMC:RESISTING_CELL_DEATH
Regulated Cell Death / DEATH_RECEPTOR_PATHWAYS
Regulated Cell Death / DNA_DAMAGE_RESPONSE
Regulated Cell Death / TNF_RESPONSE

References
PMID:11093160
PMID:16885030, PMID:16916641, PMID:19890961, PMID:12370081, PMID:10921877, PMID:21376459, PMID:21159657
PMID:18292600
AIP1 recruits phosphatase PP2A to ASK1 in tumor necrosis factor-induced ASK1-JNK activation.

PP2A*@Nucleus

References
ce_re92:( Cell Cycle DNA Repair ) PMID:16310392
ce_re355( Cell Cycle DNA Repair ):
For role of TIM1*/TIPIN in S-phase checkpoint, replication arrest, stalled replication forks stabilisation and DNA repair during S-phase:
PMID:17102137, PMID:17116885, PMID:17296725, PMID:19793801, PMID:17582221
ce_re380:( Cell Cycle DNA Repair ) PMID:16705156

PP2A*@Cytosol

Maps_Modules
HMC:RESISTING_CELL_DEATH
Regulated Cell Death / DEATH_RECEPTOR_PATHWAYS
Regulated Cell Death / DNA_DAMAGE_RESPONSE
Regulated Cell Death / TNF_RESPONSE

References
rc_re1340:( Regulated Cell Death ) from uniprot

Modifications:
In compartment: Cytosol

PP2A*@Cytosol

In compartment: Nucleus

PP2A*@Nucleus

In compartment: T_cell

PP2A*@T_cell

Participates in complexes:
In compartment: cSMAC

CTLA4:PP2A*@cSMAC

Participates in reactions:
As Reactant or Product:

CTLA4@cSMAC + PP2A*@T_cell → CTLA4:PP2A*@cSMAC

As Catalyser: