Simple molecule NO map
NO@Cytosol

Identifiers
CHEBI:16480 KEGGCOMPOUND:C00533 CAS:10102-43-9

References
PMID:10792026
Nitric oxide inhibits tumor necrosis factor-alpha-induced apoptosis by reducing the generation of ceramide.
rc_re1550( Regulated Cell Death  map ):
PMID:12387875
PMID:9841888
rc_re1562( Regulated Cell Death  map ):
PMID:12404124
NO was found to be mediated through stimulation of guanylate cyclase and to require activation of protein kinase G

NO@Mitochondrial intermembrane space

Identifiers
CHEBI:16480 KEGGCOMPOUND:C00533 CAS:10102-43-9

References
rc_re834( Regulated Cell Death  map ):
PMID:7544575
in vitro
in RAW 264.7 upon NOS2 induction (LPS+IFNg)
proposed mechanise: loss of iron sulfur cluster

NO@Mitochondrial inner membrane

Identifiers
CHEBI:16480 KEGGCOMPOUND:C00533 CAS:10102-43-9

References
rc_re90( Regulated Cell Death  map ):
PMID:8194600
cytochrome oxidase inhibition by nitric oxide

NO@default

Identifiers
CHEBI:16480 KEGGCOMPOUND:C00533 CAS:10102-43-9

References
 NATURAL_KILLER  map
PMID:22006996, PMID:18559521
Nitric oxide inhibits the hypoxia-induced expression of ADAM10 and the hypoxia-induced accumulation of HIF1A
and decrease MIC shedding.
NO attenuates in vivo tumor growth by sensitizing tumor cells to recognition and elimination by the innate immune system.

NO@INNATE_IMMUNE_CELL_Cytosol

References
PMID:15644117, PMID:17260466
HMGB1 induces NO production probably via NFkB dependent upregulation of INOS expression in rodent macrophage
PMID:24092389
TANs from early tumors are more cytotoxic toward tumor cells and produce higher levels of TNF-??, NO, and H2O2 and, in established tumors, these functions are downregulated and TAN acquire a more protumorigenic phenotype

NO@TUMOR_CELL_AS_INDUCTOR

Identifiers
CHEBI:16480 KEGGCOMPOUND:C00533 CAS:10102-43-9

References
 NATURAL_KILLER  map
PMID:22006996, PMID:18559521
Nitric oxide inhibits the hypoxia-induced expression of ADAM10 and the hypoxia-induced accumulation of HIF1A
and decrease MIC shedding.
NO attenuates in vivo tumor growth by sensitizing tumor cells to recognition and elimination by the innate immune system.

Modifications:
In compartment: Cytosol
  1. NO@Cytosol map
In compartment: INNATE_IMMUNE_CELL_Cytosol
  1. NO@INNATE_IMMUNE_CELL_Cytosol map
In compartment: Mitochondrial inner membrane
  1. NO@Mitochondrial inner membrane map
In compartment: Mitochondrial intermembrane space
  1. NO@Mitochondrial intermembrane space map
In compartment: TUMOR_CELL_AS_INDUCTOR
  1. NO@TUMOR_CELL_AS_INDUCTOR map
In compartment: default
  1. NO@default map
Participates in complexes:
    Participates in reactions:
    As Reactant or Product:
    1. NO@default map → map NO_production@default map
    2. L-arginine@INNATE_IMMUNE_CELL_Cytosol map + O_sub_2_endsub_@INNATE_IMMUNE_CELL_Cytosol map + NADPH@INNATE_IMMUNE_CELL_Cytosol map → map NO@INNATE_IMMUNE_CELL_Cytosol map + L-citrulin@INNATE_IMMUNE_CELL_Cytosol map + NADP+@INNATE_IMMUNE_CELL_Cytosol map
    3. NO@INNATE_IMMUNE_CELL_Cytosol map → map NO@default map
    4. Caspase3*@Cytosol map + NO@Cytosol map → map Caspase3*|​-SNO@Cytosol map
    5. IKK_beta_*@Cytosol map + NO@Cytosol map → map IKK_beta_*|​-SNO@Cytosol map
    6. Caspase9*|​S196_unk|​T125_unk|​S144_unk|​Y153_unk@Cytosol map + NO@Cytosol map → map Caspase9*|​S196_unk|​T125_unk|​S144_unk|​Y153_unk|​-SNO@Cytosol map
    7. NO@Cytosol map → map NO@Mitochondrial inner membrane map
    8. NO@Mitochondrial inner membrane map → map NO@Mitochondrial intermembrane space map
    9. L-arginine@Cytosol map + O_sub_2_endsub_@Cytosol map + NADPH@Cytosol map → map NO@Cytosol map + L-citrulline@Cytosol map + NADP_super_+_endsuper_@Cytosol map
    10. FECH|​hm2|​[2FE-2S]@Mitochondrial intermembrane space map + NO@Mitochondrial intermembrane space map → map FECH@Mitochondrial intermembrane space map
    As Catalyser:
    1. HIF1A@TUMOR_CELL_AS_INDUCTOR map → map HIF1A@TUMOR_CELL_AS_INDUCTOR map
    2. gADAM10@TUMOR_CELL_AS_INDUCTOR map → map rADAM10@TUMOR_CELL_AS_INDUCTOR map
    3. Sphingomyelin@Cytosol map + H2O@Cytosol map → map Ceramide@Cytosol map + Choline Phosphate@Cytosol map
    4. GUCY*@Cytosol map → map GUCY*@Cytosol map
    5. ACER*@Cytosol map → map ACER*|​ubi@Cytosol map
    6. Cytochrome_C*|​ferroheme:​cardiolipin@Mitochondrial inner membrane map + H+@Mitochondrial Matrix map + O_sub_2_endsub_@Mitochondrial inner membrane map → map Cytochrome_C*|​ferriheme:​cardiolipin@Mitochondrial inner membrane map + H+@Mitochondrial intermembrane space map