Protein Cleaved DCC* map

Identifiers
deleted in colorectal carcinoma
HUGO:DCC HGNC:2701 ENTREZ:1630 UNIPROT:P43146

Maps_Modules
HMC:RESISTING_CELL_DEATH
 Regulated Cell Death  map  / DEATH_RECEPTOR_PATHWAYS  map
 Regulated Cell Death  map  / DEPENDANCE_RECEPTORS  map

References
PMID:22920895
in the absence of his ligand, DCC is cleaved and induce apoptosis

Cleaved DCC*@Cytosol

Maps_Modules
HMC:RESISTING_CELL_DEATH
 Regulated Cell Death  map  / DEATH_RECEPTOR_PATHWAYS  map
 Regulated Cell Death  map  / DEPENDANCE_RECEPTORS  map

References
rc_re1690( Regulated Cell Death  map ):
PMID:19543238
Interfering with multimerization of netrin-1 receptors triggers tumor cell death
rc_re1692( Regulated Cell Death  map ):
PMID:12011067
DCC interacts with both caspase-3 and caspase-9 and drives the activation of caspase-3 through caspase-9

Modifications:
In compartment: Cytosol
  1. Cleaved DCC*@Cytosol map
Participates in complexes:
In compartment: Cytosol
  1. APPL2:​Caspase9*:​Cleaved DCC*@Cytosol map
  2. APPL2:​Cleaved DCC*:​cleaved~Caspase9*@Cytosol map
Participates in reactions:
As Reactant or Product:
  1. APPL2:​Caspase9*:​Cleaved DCC*@Cytosol map → map APPL2:​Cleaved DCC*:​cleaved~Caspase9*@Cytosol map
  2. Caspase3*:​DCC:​NTN1@Cytosol map → map NTN1@Extracellular space map + Cleaved DCC*@Cytosol map
  3. APPL2@Cytosol map + Cleaved DCC*@Cytosol map + Caspase9*@Cytosol map → map APPL2:​Caspase9*:​Cleaved DCC*@Cytosol map
As Catalyser:
  1. Caspase3*@Cytosol map → map cleaved~Caspase3*@Cytosol map