Protein TERT map

Identifiers
telomerase reverse transcriptase

Maps_Modules
HMC:ACTIVATING_INVASION_AND_METASTASIS
 EMT Senescence  map  / EMT_REGULATORS  map
 EMT Senescence  map  / SENESCENCE  map

References
PMID:11283614
Myc: an ubiquitous mediator of cell growth and proliferation
Myc can both activate and repress transcription, depending on the nature of associated factors
TGFB downregulates Myc to cause cell cycle arrest.
TGFB activates p15INK4B and/or p21CIP1 (inhibitor of CDKs) ==> CDK inhibition by TGFB
TGFB downregulates cdc25A (a phosphatase, activator of CDKs) ==> CDK inhibition by TGFB
PMID:2191300
Interaction of an NF-kappa B-like factor with a site upstream of the c-myc promoter.
PMID??:28536364
c-myc is transcriptionally upregulated by NF-??B
PMID:20027199
MYC induces DNA damage throuh an increase in ROS production, innapropriate DNA synthesis and abrogation of DNA repair
PMID:20713526
MYC supress the activity of anti-apoptotic BCL2 and BCLXL (BCL2L1) genes
PMID??:20713526
MYC in complex with CDK2 alone inhibit senescence through the inhibition of p16 and p21 expression as well as TERT and BMI1 expression increase. MYC in complex with CDK2 and p27KIP1 induces senescence through the expression increase of p16 and p21 as well as TERT and BMI1 expression decrease. WRN inhibit MYC induced senescence.
PMID??: PMID:17055429
MYC stimulate P53 and ARF
PMID:23551398

TERT@Cytosol

References
te_re93:( Telomere Maintenance  map ) PMID:10197982 PMID:21945180 PMID:23551398
te_re98:( Telomere Maintenance  map ) PMID:22032831 PMID:15805468 PMID:20473778
te_re105:( Telomere Maintenance  map ) PMID:22032831 PMID:10837221 PMID:1675600

TERT|​ubi@Cytosol

References
te_re98:( Telomere Maintenance  map ) PMID:22032831 PMID:15805468 PMID:20473778

Modifications:
In compartment: Cytosol
  1. TERT@Cytosol map
  2. TERT|​ubi@Cytosol map
In compartment: Nucleus
  1. TERT@Nucleus map
Participates in complexes:
In compartment: Cytosol
  1. ABL1:​TERT@Cytosol map
  2. ABL1:​TERT|​pho@Cytosol map
  3. HSP90*|​hm2:​PTGES3:​TERT@Cytosol map
  4. HSP90*|​hm2:​PTGES3:​TERT|​S227_pho@Cytosol map
  5. HSP70*:​HSP90*|​hm2:​STUB1:​TERT@Cytosol map
  6. HSP70*:​HSP90*|​hm2:​STUB1:​TERT|​ubi@Cytosol map
  7. HSP70*:​HSP90*|​hm2:​PTGES3:​STUB1:​TERT@Cytosol map
In compartment: Nucleus
  1. HSP90*|​hm2:​PTGES3:​TERT|​S227_pho@Nucleus map
  2. DKC1:​GAR1:​HSP90*|​hm2:​NHP2:​NOP10:​PTGES3:​TERC:​TERT|​S227_pho:​WRAP53@Nucleus map
In compartment: cajal body
  1. HSP90*|​hm2:​PTGES3:​TERT|​S227_pho@cajal body map
  2. DKC1:​GAR1:​HSP90*|​hm2:​NHP2:​NOP10:​PTGES3:​TERC:​TERT|​S227_pho:​WRAP53@cajal body map
Participates in reactions:
As Reactant or Product:
  1. rTERT@Nucleus map → map TERT@Nucleus map
  2. HSP90*|​hm2:​PTGES3:​TERT@Cytosol map + STUB1@Cytosol map + HSP70*@Cytosol map → map HSP70*:​HSP90*|​hm2:​PTGES3:​STUB1:​TERT@Cytosol map
  3. HSP70*:​HSP90*|​hm2:​PTGES3:​STUB1:​TERT@Cytosol map → map HSP70*:​HSP90*|​hm2:​STUB1:​TERT@Cytosol map + PTGES3@Cytosol map
  4. TERT@Cytosol map + ABL1@Cytosol map → map ABL1:​TERT@Cytosol map
  5. ABL1:​TERT@Cytosol map → map ABL1:​TERT|​pho@Cytosol map
  6. DKC1:​GAR1:​HSP90*|​hm2:​NHP2:​NOP10:​PTGES3:​TERC:​TERT|​S227_pho:​WRAP53@cajal body map → map DKC1:​GAR1:​HSP90*|​hm2:​NHP2:​NOP10:​PTGES3:​TERC:​TERT|​S227_pho:​WRAP53@Nucleus map
  7. DKC1:​GAR1:​HSP90*|​hm2:​NHP2:​NOP10:​PTGES3:​TERC:​TERT|​S227_pho:​WRAP53@Nucleus map → map DKC1:​GAR1:​HSP90*|​hm2:​NHP2:​NOP10:​PTGES3:​TERC:​TERT|​S227_pho:​WRAP53@Nucleus map
  8. DKC1:​GAR1:​HSP90*|​hm2:​NHP2:​NOP10:​PTGES3:​TERC:​TERT|​S227_pho:​WRAP53@Nucleus map → map degraded
  9. HSP70*:​HSP90*|​hm2:​STUB1:​TERT@Cytosol map → map HSP70*:​HSP90*|​hm2:​STUB1:​TERT|​ubi@Cytosol map
  10. HSP70*:​HSP90*|​hm2:​STUB1:​TERT|​ubi@Cytosol map → map degraded
  11. DKC1:​GAR1:​HSP90*|​hm2:​NHP2:​NOP10:​PTGES3:​TERC:​TERT|​S227_pho:​WRAP53@Nucleus map → map Telomerase recruitment@Nucleus map
  12. Telomerase recruitment@Nucleus map + DKC1:​GAR1:​HSP90*|​hm2:​NHP2:​NOP10:​PTGES3:​TERC:​TERT|​S227_pho:​WRAP53@Nucleus map → map DKC1:​GAR1:​HSP90*|​hm2:​NHP2:​NOP10:​PTGES3:​TERC:​TERT|​S227_pho:​WRAP53@Nucleus map
  13. rTERT@Cytosol map → map TERT@Cytosol map
  14. TERT@Cytosol map + HSP90*|​hm2@Cytosol map + PTGES3@Cytosol map → map HSP90*|​hm2:​PTGES3:​TERT@Cytosol map
  15. HSP90*|​hm2:​PTGES3:​TERT@Cytosol map → map HSP90*|​hm2:​PTGES3:​TERT|​S227_pho@Cytosol map
  16. HSP90*|​hm2:​PTGES3:​TERT|​S227_pho@Cytosol map → map HSP90*|​hm2:​PTGES3:​TERT|​S227_pho@Nucleus map
  17. HSP90*|​hm2:​PTGES3:​TERT|​S227_pho@cajal body map + DKC1:​GAR1:​NHP2:​NOP10:​TERC:​WRAP53@cajal body map → map DKC1:​GAR1:​HSP90*|​hm2:​NHP2:​NOP10:​PTGES3:​TERC:​TERT|​S227_pho:​WRAP53@cajal body map
  18. HSP90*|​hm2:​PTGES3:​TERT|​S227_pho@Nucleus map → map HSP90*|​hm2:​PTGES3:​TERT|​S227_pho@cajal body map
  19. TERT@Cytosol map → map TERT|​ubi@Cytosol map
  20. TERT|​ubi@Cytosol map → map degraded
As Catalyser:
  1. Nucleotides@Nucleus map → map gTelomeric G-Strand@Nucleus map