Identifiers
apoptotic peptidase activating factor 1
HUGO:APAF1 HGNC:576 ENTREZ:317 UNIPROT:O14727
HUGO:APAF1 HGNC:576 ENTREZ:317 UNIPROT:O14727 GENECARDS:APAF1 REACTOME:50100 KEGG:317 ATLASONC:APAF1ID422 WIKI:APAF1
Maps_Modules
HMC:RESISTING_CELL_DEATH
Regulated Cell Death / APOPTOSIS
Regulated Cell Death / CASPASES
Regulated Cell Death / DEATH_RECEPTOR_PATHWAYS
Regulated Cell Death / MOMP_REGULATION
HMC:EVADING_GROWTH_SUPPRESSORS
Survival / PI3K_AKT_MTOR
References
PMID:19788417
PMID:16977332
Maps_Modules
HMC:RESISTING_CELL_DEATH
Regulated Cell Death / APOPTOSIS
Regulated Cell Death / CASPASES
Regulated Cell Death / DEATH_RECEPTOR_PATHWAYS
Regulated Cell Death / MOMP_REGULATION
References
rc_re482( Regulated Cell Death ):
PMID:17377525
review on apoptosome formation
PMID:11864614
stoechiometry apoptosome
PMID:12522243
inhibition of apoptosome formation by prothymosin-alpha
PMID:15087373
in HT-29 colon adenocarcinoma cells, siRNA against ACHE prevents the APAF1:CYCS interaction and etoposide-induced
PMID:14622304
AFP positive influence on apoptosome assembly
PMID:18439902
CAS PHAPI and HSP70 enhance apoptosome formation and caspase activation
rc_re485:( Regulated Cell Death ) PMID:10949025
rc_re486( Regulated Cell Death ):
PMID:10934467
in 293, HeLa and Jurkat cells, interaction HSP70 - APAF1
in vitro, the interaction is ATP dependent
HSP70 interactions competes for oligomerization and formation of the apoptosome
PMID:10934466
in vitro, HSP70 blocks the recruitment of CASP9 into the apoptosome by binding to APAF1
rc_re487:( Regulated Cell Death ) PMID:15262985
rc_re488:( Regulated Cell Death ) PMID:10944114
→ APAF1@Cytosol
+ (d)ATP@Cytosol + APAF1@Cytosol → (d)ATP:APAF1:Cytochrome_C*|ferroheme@Cytosol
+ AVEN@Cytosol → APAF1:AVEN@Cytosol
+ HSP70*@Cytosol → rc_s1590
+ APIP@Cytosol → APAF1:APIP@Cytosol
+ HSP90*@Cytosol → APAF1:HSP90*@Cytosol
+ APAF1:Caspase9*@Cytoplasm + Cytochrome_C*@Cytoplasm → APAF1:Caspase9*:Cytochrome_C*:dATP/ATP@Cytoplasm