Protein IRE1-alpha* map

Identifiers
endoplasmic reticulum to nucleus signaling 1
HUGO:ERN1 hgnc_id:HGNC:3449 HGNC:3449 ENTREZ:2081 UNIPROT:O75460

Maps_Modules
HMC:RESISTING_CELL_DEATH
 Regulated Cell Death  map  / ER_STRESS  map

References
PMID:23850759
PMID:26587781
PMID:23430059
Under mild ER stress BH3-only proteins Bim and PUMA bind IRE1a, via their BH3 domain, and stimulate its RNase activity

Modifications:
In compartment: Cytosol
  1. IRE1-alpha*@Cytosol map
In compartment: Endopasmic Reticulum
  1. IRE1-alpha*@Endopasmic Reticulum map
Participates in complexes:
In compartment: Endopasmic Reticulum
  1. BCL2L11:​DYNLL1@Endopasmic Reticulum map
  2. BAX:​IRE1-alpha*@Endopasmic Reticulum map
  3. BAK1:​IRE1-alpha*@Endopasmic Reticulum map
  4. BBC3:​IRE1-alpha*@Endopasmic Reticulum map
  5. IRE1-alpha*:​RIPK1@Endopasmic Reticulum map
  6. HSP70*:​IRE1-alpha*@Endopasmic Reticulum map
  7. IRE1-alpha*:​TMBIM6@Endopasmic Reticulum map
  8. BCL2L11:​IRE1-alpha*@Endopasmic Reticulum map
  9. IRE1-alpha*:​Unfolded protein*@Endopasmic Reticulum map
  10. MCL1|​pho|​hm2:​TRAF2:​Unfolded protein*@Endopasmic Reticulum map
Participates in reactions:
As Reactant or Product:
  1. IRE1-alpha*@Endopasmic Reticulum map + Unfolded protein*@Endopasmic Reticulum map → map IRE1-alpha*:​Unfolded protein*@Endopasmic Reticulum map
  2. IRE1-alpha*@Endopasmic Reticulum map → map expression of ER chaperones@Endopasmic Reticulum map
  3. MCL1|​pho|​hm2:​TRAF2:​Unfolded protein*@Endopasmic Reticulum map → map mRNA translation@Cytosol map
  4. IRE1-alpha*@Endopasmic Reticulum map → map retrograde transport from ER to cytosol@Endopasmic Reticulum map
  5. IRE1-alpha*:​Unfolded protein*@Endopasmic Reticulum map + TRAF2@Cytosol map → map MCL1|​pho|​hm2:​TRAF2:​Unfolded protein*@Endopasmic Reticulum map
  6. rIRE1-alpha*@Nucleus map → map IRE1-alpha*@Cytosol map
  7. MCL1|​pho|​hm2:​TRAF2:​Unfolded protein*@Endopasmic Reticulum map → map RIDD process@Cytosol map
  8. MCL1|​pho|​hm2:​TRAF2:​Unfolded protein*@Endopasmic Reticulum map → map RIDD process@Cytosol map
  9. IRE1-alpha*@Endopasmic Reticulum map + TMBIM6@Endopasmic Reticulum map → map IRE1-alpha*:​TMBIM6@Endopasmic Reticulum map
  10. IRE1-alpha*@Endopasmic Reticulum map + BAK1@Endopasmic Reticulum map → map BAK1:​IRE1-alpha*@Endopasmic Reticulum map
  11. BCL2L11:​DYNLL1@Endopasmic Reticulum map → map BiP*@Endopasmic Reticulum map + IRE1-alpha*@Endopasmic Reticulum map
  12. IRE1-alpha*@Endopasmic Reticulum map + RIPK1@Endopasmic Reticulum map → map IRE1-alpha*:​RIPK1@Endopasmic Reticulum map
  13. MCL1|​pho|​hm2:​TRAF2:​Unfolded protein*@Endopasmic Reticulum map → map UPR@Cytosol map
  14. MCL1|​pho|​hm2:​TRAF2:​Unfolded protein*@Endopasmic Reticulum map → map adaptative response@Cytosol map
  15. IRE1-alpha*@Endopasmic Reticulum map + BCL2L11@Endopasmic Reticulum map → map BCL2L11:​IRE1-alpha*@Endopasmic Reticulum map
  16. IRE1-alpha*@Endopasmic Reticulum map + BBC3@Endopasmic Reticulum map → map BBC3:​IRE1-alpha*@Endopasmic Reticulum map
  17. IRE1-alpha*@Endopasmic Reticulum map + HSP70*@Endopasmic Reticulum map → map HSP70*:​IRE1-alpha*@Endopasmic Reticulum map
As Catalyser:
  1. IRE1-alpha*:​Unfolded protein*@Endopasmic Reticulum map + TRAF2@Cytosol map → map MCL1|​pho|​hm2:​TRAF2:​Unfolded protein*@Endopasmic Reticulum map
  2. ruXBP1@Nucleus map → map rsXBP1@Nucleus map
  3. rIRE1-alpha*@Nucleus map → map rIRE1-alpha*@Nucleus map
  4. TRAF2@Cytosol map → map TRAF2@Cytosol map
  5. ASK1*@Cytosol map → map ASK1*|​pho|​active@Cytosol map
  6. CHUK:​IKBKB@Cytosol map → map CHUK:​SDHC|​pho|​pho@Cytosol map