Identifiers
cytochrome c, somatic
HUGO:CYCS HGNC:19986 ENTREZ:54205 UNIPROT:P99999
HUGO:CYCS HGNC:19986 ENTREZ:54205 UNIPROT:P99999 GENECARDS:CYCS REACTOME:53260 KEGG:54205 ATLASONC:GC_CYCS WIKI:CYCS

Maps_Modules
HMC:RESISTING_CELL_DEATH
HMC:DEREGULATING_CELLULAR_ENERGETICS
 Regulated Cell Death   / ANTIOXIDANT_RESPONSE 
 Regulated Cell Death   / APOPTOSIS 
 Regulated Cell Death   / CASPASES 
 Regulated Cell Death   / DEATH_RECEPTOR_PATHWAYS 
 Regulated Cell Death   / MITOCHONDRIAL_GENES 
 Regulated Cell Death   / MITOCHONDRIAL_METABOLISM 
 Regulated Cell Death   / MOMP_REGULATION 
 Regulated Cell Death   / OXIDATIVE_PHOSPHOYLATION_AND_TCA_CYCLE 
 Regulated Cell Death   / ER_STRESS 
HMC:EVADING_GROWTH_SUPPRESSORS
 Survival   / PI3K_AKT_MTOR 

References
PMID:23850759
synonym:cytochrome_c
PMID:19788417
PMID:16977332

Maps_Modules
HMC:RESISTING_CELL_DEATH
HMC:DEREGULATING_CELLULAR_ENERGETICS
 Regulated Cell Death   / ANTIOXIDANT_RESPONSE 
 Regulated Cell Death   / APOPTOSIS 
 Regulated Cell Death   / CASPASES 
 Regulated Cell Death   / DEATH_RECEPTOR_PATHWAYS 
 Regulated Cell Death   / MITOCHONDRIAL_GENES 
 Regulated Cell Death   / MITOCHONDRIAL_METABOLISM 
 Regulated Cell Death   / MOMP_REGULATION 
 Regulated Cell Death   / OXIDATIVE_PHOSPHOYLATION_AND_TCA_CYCLE 

References
rc_re1:( Regulated Cell Death  ) hierarchical:post-MOMP
rc_re482( Regulated Cell Death  ):
PMID:17377525
review on apoptosome formation
PMID:11864614
stoechiometry apoptosome
PMID:12522243
inhibition of apoptosome formation by prothymosin-alpha
PMID:15087373
in HT-29 colon adenocarcinoma cells, siRNA against ACHE prevents the APAF1:CYCS interaction and etoposide-induced
PMID:14622304
AFP positive influence on apoptosome assembly
PMID:18439902
CAS PHAPI and HSP70 enhance apoptosome formation and caspase activation
rc_re483( Regulated Cell Death  ):
PMID:10980706
PMID:10544189

Maps_Modules
HMC:RESISTING_CELL_DEATH
HMC:DEREGULATING_CELLULAR_ENERGETICS
 Regulated Cell Death   / ANTIOXIDANT_RESPONSE 
 Regulated Cell Death   / APOPTOSIS 
 Regulated Cell Death   / CASPASES 
 Regulated Cell Death   / DEATH_RECEPTOR_PATHWAYS 
 Regulated Cell Death   / MITOCHONDRIAL_GENES 
 Regulated Cell Death   / MITOCHONDRIAL_METABOLISM 
 Regulated Cell Death   / MOMP_REGULATION 
 Regulated Cell Death   / OXIDATIVE_PHOSPHOYLATION_AND_TCA_CYCLE 

Maps_Modules
HMC:RESISTING_CELL_DEATH
HMC:DEREGULATING_CELLULAR_ENERGETICS
 Regulated Cell Death   / ANTIOXIDANT_RESPONSE 
 Regulated Cell Death   / APOPTOSIS 
 Regulated Cell Death   / CASPASES 
 Regulated Cell Death   / DEATH_RECEPTOR_PATHWAYS 
 Regulated Cell Death   / MITOCHONDRIAL_GENES 
 Regulated Cell Death   / MITOCHONDRIAL_METABOLISM 
 Regulated Cell Death   / MOMP_REGULATION 
 Regulated Cell Death   / OXIDATIVE_PHOSPHOYLATION_AND_TCA_CYCLE 

References
s_akt1_re177:( Survival  ) PMID:20709625

References
s_akt1_re177:( Survival  ) PMID:20709625
s_akt1_re178( Survival  ):
PMID:19788417
PMID:16977332

1. Cytochrome_C*@Cytoplasm

1. Cytochrome_C*@Cytosol
2. Cytochrome_C*|​ferroheme@Cytosol

1. Cytochrome_C*@Mitochondria

1. Cytochrome_C*@Mitochondria inner membrane

1. Cytochrome_C*@Mitochondrial intermembrane space
2. Cytochrome_C*|​ferroheme@Mitochondrial intermembrane space

1. APAF1:​Caspase9*:​Cytochrome_C*:​dATP/ATP@Cytoplasm

1. Cytochrome_C*|​ferroheme:​HSPB1@Cytosol
2. (d)ATP:​APAF1:​Cytochrome_C*|​ferroheme@Cytosol

1. Cytochrome_C*|​ferriheme:​cardiolipin@Mitochondrial inner membrane
2. Cytochrome_C*|​ferroheme:​cardiolipin@Mitochondrial inner membrane

1. Cytochrome_C*|​ferroheme@Mitochondrial intermembrane space → Cytochrome_C*|​ferroheme@Cytosol
2. Cytochrome_C*@Mitochondria inner membrane → Cytochrome_C*@Cytosol
3. Cytochrome_C*|​ferroheme@Cytosol + (d)ATP@Cytosol + APAF1@Cytosol → (d)ATP:​APAF1:​Cytochrome_C*|​ferroheme@Cytosol
4. Cytochrome_C*|​ferroheme@Cytosol + HSPB1@Cytosol → Cytochrome_C*|​ferroheme:​HSPB1@Cytosol
5. Cytochrome_C*|​ferriheme:​cardiolipin@Mitochondrial inner membrane + H+@Mitochondrial Matrix + ubiquinol@Mitochondrial inner membrane → Cytochrome_C*|​ferroheme:​cardiolipin@Mitochondrial inner membrane + H+@Mitochondrial intermembrane space + ubiquinone@Mitochondrial inner membrane
6. Cytochrome_C*|​ferroheme:​cardiolipin@Mitochondrial inner membrane + H+@Mitochondrial Matrix + O_sub_2_endsub_@Mitochondrial inner membrane → Cytochrome_C*|​ferriheme:​cardiolipin@Mitochondrial inner membrane + H+@Mitochondrial intermembrane space
7. Cytochrome_C*|​ferroheme:​cardiolipin@Mitochondrial inner membrane + O_sub_2_endsub_@Mitochondrial intermembrane space → Cytochrome_C*|​ferriheme:​cardiolipin@Mitochondrial inner membrane + H_sub_2_endsub_O_sub_2_endsub_@Mitochondrial intermembrane space
8. Cytochrome_C*@Mitochondrial intermembrane space + ferroheme b@Mitochondrial intermembrane space → Cytochrome_C*|​ferroheme@Mitochondrial intermembrane space
9. Cytochrome_C*|​ferroheme@Mitochondrial intermembrane space + cardiolipin@Mitochondrial inner membrane → Cytochrome_C*|​ferroheme:​cardiolipin@Mitochondrial inner membrane
10. Cytochrome_C*|​ferroheme:​cardiolipin@Mitochondrial inner membrane + H_sub_2_endsub_O_sub_2_endsub_@Mitochondrial intermembrane space → Cytochrome_C*|​ferroheme@Mitochondrial intermembrane space + oxidized_cardiolipin@Mitochondrial inner membrane
11. rCytochrome_C*@Nucleus → Cytochrome_C*@Mitochondrial intermembrane space
12. Cytochrome_C*@Mitochondria → Cytochrome_C*@Cytoplasm
13. dATP/ATP@Cytoplasm + APAF1:​Caspase9*@Cytoplasm + Cytochrome_C*@Cytoplasm → APAF1:​Caspase9*:​Cytochrome_C*:​dATP/ATP@Cytoplasm

1. Caspase9*@Cytosol → cleaved~Caspase9*@Cytosol
2. Caspase9*@Cytoplasm → Caspase9__sub_TRUNC_endsub_*@Cytoplasm