Reaction state_transition rc_re482 map

Cytochrome_C*|​ferroheme@Cytosol map + (d)ATP@Cytosol map + APAF1@Cytosol map → (d)ATP:​APAF1:​Cytochrome_C*|​ferroheme@Cytosol map

Reaction regulators:
Boolean_logic_gate_and
  1. ANP32A@Cytosol map and CSE1L@Cytosol map and
Catalysis
  1. AFP@Cytosol map
  2. ANP32A@Cytosol map
  3. CSE1L@Cytosol map
  4. HSP70*@Cytosol map
Inhibition
  1. PTMA@Cytosol map
Unknown_catalysis
  1. ACHE@Cytosol map


References
PMID:17377525
review on apoptosome formation
PMID:11864614
stoechiometry apoptosome
PMID:12522243
inhibition of apoptosome formation by prothymosin-alpha
PMID:15087373
in HT-29 colon adenocarcinoma cells, siRNA against ACHE prevents the APAF1:CYCS interaction and etoposide-induced
PMID:14622304
AFP positive influence on apoptosome assembly
PMID:18439902
CAS PHAPI and HSP70 enhance apoptosome formation and caspase activation