Protein MYD88 map

Identifiers
myeloid differentiation primary response 88
HUGO:MYD88 hgnc_id:HGNC:7562 HGNC:7562 ENTREZ:4615 UNIPROT:Q99836
HUGO:MYD88
"myeloid differentiation primary response gene (88)"
HUGO:MYD88 HGNC:7562 ENTREZ:4615 UNIPROT:Q99836

Maps_Modules
HMC:TUMOR_PROMOTING_INFLAMMATION
HMC:ACTIVATING_INVASION_AND_METASTASIS
 Cancer Associated Fibroblasts  map  / INFLAMMATORY_SIGNALING_PATHWAYS  map
HMC:AVOIDING_IMMUNE_DESTRUCTION
 Innate Immunity  map  / IMMUNOSTIMULATORY_CYTOKINE_PATHWAYS  map
HMC:EVADING_GROWTH_SUPPRESSORS
 Survival  map  / MAPK  map

References
PMID:14660645, PMID:16878026, PMID:23681101
The adaptor proteins MyD88 and TIRAP associate with TLR 2 and TLR 4 after receptor engagement.
PMID:23811849
HMGB1 is a nuclear nonhistone chromatin-binding protein. It is secreted at the late stages of cellular demise and iactivates TLR4/MyD88 pathway in dendritic cells (DCs) to accelerate the processing of phagocytic cargo in the DC and to facilitate antigen presentation by DC to T cells.
PMID:17704786
DCs require signaling through TLR4 and its adaptor MyD88 for efficient processing and cross-presentation of antigen from dying tumor cells.
The IL-1R/IL-1RAcP heterodimer recruits the death domain adapter protein MyD88.
PMID:11274345

MYD88@Cytoplasm

References
su_mpk1_mpk1_re126( Survival  map ):
The IL-1R/IL-1RAcP heterodimer recruits the death domain adapter protein MyD88.
PMID:11274345

Modifications:
In compartment: Cytoplasm
  1. MYD88@Cytoplasm map
In compartment: Cytosol
  1. MYD88@Cytosol map
In compartment: INNATE_IMMUNE_CELL_Membrane
  1. MYD88@INNATE_IMMUNE_CELL_Membrane map
Participates in complexes:
In compartment: Cytoplasm
  1. IL1R1:​IRAK1:​MYD88:​TAK1*|​pho:​TRAF6@Cytoplasm map
In compartment: Cytosol
  1. IL1R1:​IL1RAP:​IRAK4:​MYD88@Cytosol map
In compartment: INNATE_IMMUNE_CELL_Membrane
  1. IL18:​IL18R1:​IL18RAP:​MYD88@INNATE_IMMUNE_CELL_Membrane map
  2. CD14:​LY96:​MYD88:​TIRAP:​TLR2/4*@INNATE_IMMUNE_CELL_Membrane map
  3. IL18:​IL18R1:​IL18RAP:​IRAK4:​MYD88@INNATE_IMMUNE_CELL_Membrane map
  4. CD14:​IRAK2:​IRAK4:​LY96:​MYD88:​TIRAP:​TLR2/4*@INNATE_IMMUNE_CELL_Membrane map
In compartment: Plasma Membrane
  1. IL1R1:​MYD88@Plasma Membrane map
  2. IL1R1:​IRAK1:​MYD88@Plasma Membrane map
  3. IL1R1:​IRAK1:​MYD88:​TRAF6@Plasma Membrane map
Participates in reactions:
As Reactant or Product:
  1. IL1R1:​IL1RAP@Cytosol map + MYD88@Cytosol map + IRAK4@Cytosol map → map IL1R1:​IL1RAP:​IRAK4:​MYD88@Cytosol map
  2. IL18:​IL18R1:​IL18RAP:​MYD88@INNATE_IMMUNE_CELL_Membrane map → map RECRUITMENT_OF_IMMUNE_CELLS@INNATE_IMMUNE_CELL_Cytosol map
  3. IL18@default map + IL18R1:​IL18RAP@INNATE_IMMUNE_CELL_Membrane map + MYD88@INNATE_IMMUNE_CELL_Membrane map → map IL18:​IL18R1:​IL18RAP:​MYD88@INNATE_IMMUNE_CELL_Membrane map
  4. TLR2/4*@INNATE_IMMUNE_CELL_Membrane map + LY96@INNATE_IMMUNE_CELL_Membrane map + TIRAP@INNATE_IMMUNE_CELL_Membrane map + MYD88@INNATE_IMMUNE_CELL_Membrane map + CD14@INNATE_IMMUNE_CELL_Membrane map → map CD14:​LY96:​MYD88:​TIRAP:​TLR2/4*@INNATE_IMMUNE_CELL_Membrane map
  5. IRAK2@INNATE_IMMUNE_CELL_Membrane map + IRAK4@INNATE_IMMUNE_CELL_Membrane map + CD14:​LY96:​MYD88:​TIRAP:​TLR2/4*@INNATE_IMMUNE_CELL_Membrane map → map CD14:​IRAK2:​IRAK4:​LY96:​MYD88:​TIRAP:​TLR2/4*@INNATE_IMMUNE_CELL_Membrane map
  6. rMYD88@INNATE_IMMUNE_CELL_Cytosol map → map MYD88@INNATE_IMMUNE_CELL_Membrane map
  7. IL18@default map + IL18R1:​IL18RAP@INNATE_IMMUNE_CELL_Membrane map + MYD88@INNATE_IMMUNE_CELL_Membrane map + IRAK4@INNATE_IMMUNE_CELL_Membrane map → map IL18:​IL18R1:​IL18RAP:​IRAK4:​MYD88@INNATE_IMMUNE_CELL_Membrane map
  8. MYD88@Cytoplasm map + IL1R1@Plasma Membrane map → map IL1R1:​MYD88@Plasma Membrane map
  9. IRAK1@Cytoplasm map + IL1R1:​MYD88@Plasma Membrane map → map IL1R1:​IRAK1:​MYD88@Plasma Membrane map
  10. TRAF6@Cytoplasm map + IL1R1:​IRAK1:​MYD88@Plasma Membrane map → map IL1R1:​IRAK1:​MYD88:​TRAF6@Plasma Membrane map
  11. TAK1*@Cytoplasm map + IL1R1:​IRAK1:​MYD88:​TRAF6@Plasma Membrane map → map IL1R1:​IRAK1:​MYD88:​TAK1*|​pho:​TRAF6@Cytoplasm map
As Catalyser:
  1. IRAK1@Cytosol map → map IRAK1|​pho|​active@Cytosol map
  2. CCL3@INNATE_IMMUNE_CELL_Cytosol map → map CCL3@default map
  3. gSOCS3@INNATE_IMMUNE_CELL_Cytosol map → map rSOCS3@INNATE_IMMUNE_CELL_Cytosol map
  4. TGFB*@INNATE_IMMUNE_CELL_Cytosol map → map TGFB*@default map
  5. CCL2@INNATE_IMMUNE_CELL_Cytosol map → map CCL2@default map
  6. VEGFA@INNATE_IMMUNE_CELL_Cytosol map → map VEGFA@default map
  7. CXCL2@INNATE_IMMUNE_CELL_Cytosol map → map CXCL2@default map
  8. gIDO1@INNATE_IMMUNE_CELL_Cytosol map → map rIDO1@INNATE_IMMUNE_CELL_Cytosol map
  9. TIMP2@INNATE_IMMUNE_CELL_Cytosol map → map TIMP2@INNATE_IMMUNE_CELL_Membrane map
  10. TIMP1@INNATE_IMMUNE_CELL_Cytosol map → map TIMP1@INNATE_IMMUNE_CELL_Membrane map
  11. gIL10@INNATE_IMMUNE_CELL_Cytosol map → map rIL10@INNATE_IMMUNE_CELL_Cytosol map
  12. Caspase1*:​NLRP3:​PYCARD@INNATE_IMMUNE_CELL_Cytosol map → map (NLRP3:​PYCARD:​cleaved Caspase1*)|​active@INNATE_IMMUNE_CELL_Cytosol map
  13. gIL6@INNATE_IMMUNE_CELL_Cytosol map → map rIL6@INNATE_IMMUNE_CELL_Cytosol map
  14. gCXCL10@INNATE_IMMUNE_CELL_Cytosol map → map rCXCL10@INNATE_IMMUNE_CELL_Cytosol map
  15. gIL23A@INNATE_IMMUNE_CELL_Cytosol map → map rIL23A@INNATE_IMMUNE_CELL_Cytosol map
  16. IRAK1@INNATE_IMMUNE_CELL_Cytosol map → map IRAK1|​pho|​active@INNATE_IMMUNE_CELL_Cytosol map
  17. gFLT3@INNATE_IMMUNE_CELL_Cytosol map → map rFLT3@INNATE_IMMUNE_CELL_Cytosol map
  18. MAP2K6@Cytoplasm map → map MAP2K6|​pho|​pho@Cytoplasm map