Identifiers
NAME:PTEN:_beta_-Arrestin*
References
s_wnc1_re152( Survival ):
Binding of beta-arrestin to PTEN increases the lipid phosphatase activity of PTEN which converts PIP3 to PIP2. Active ROCK stimulates this complex formation
PMID:21642958
ROCK phosphorylates PTEN which is than activated. Activated PTEN reduces the concentration of PIP3
PMID:15793569
PMID:20008297
s_wnc1_re154( Survival ):
PTEN contains a C2-domain which inhibits cell migration. This inhibition works only when T383 is not phosphorylated
PMID:14976311
However, beta-arrestin can also bind PTEN in this C2-region thereby dis-inhibiting migration.
su_wnc1_s_wnc1_re154( Survival ):
→ PI3K AKT MTOR pathway@Cytoplasm
+ PTEN@Cytoplasm → PTEN|pho|pho|pho|pho:_beta_-Arrestin*@Cytoplasm
→ Cell migration@Nucleus