+ COX5A@Mitochondrial inner membrane + COX6A*@Mitochondrial inner membrane + COX5B@Mitochondrial inner membrane + COX7A*@Mitochondrial inner membrane + heme a@Mitochondrial intermembrane space + MT-CO3@Mitochondrial inner membrane + Cu2+:MT-CO2@Mitochondrial inner membrane → COX4I1:COX5A:COX5B:COX6A*:COX6B*:COX6C:COX7A*:COX7B*:COX7C:COX8*:Cu2+:MT-CO1:MT-CO2:MT-CO3:heme a@Mitochondrial inner membrane References
PMID:15119951
SURF1 mutations are associated with Leigh syndrome (cytochrome oxidase deficiency)
PMID:11389896
SURF1 Homolog of Yeast (Shy) is necessary for COX assembly and stability
PMID:19625251
Paroccocus denitrificans SURF1 homologs were proposed to promote heme a insertion into COX subunit 1