Protein PDGF family* map

Identifiers
platelet-derived growth factor alpha polypeptide
HUGO:PDGFA HGNC:8799 ENTREZ:5154 UNIPROT:P04085
platelet-derived growth factor beta polypeptide
HUGO:PDGFA HGNC:8800 ENTREZ:5155 UNIPROT:P01127
platelet derived growth factor C
HUGO:PDGFC HGNC:8801 ENTREZ:56034 UNIPROT:Q9NRA1
platelet derived growth factor D
HUGO:PDGFD HGNC:30620 ENTREZ:80310 UNIPROT:Q9GZP0

Maps_Modules
HMC:ACTIVATING_INVASION_AND_METASTASIS
 EMT Senescence  map  / EMT_REGULATORS  map
 EMT Senescence  map  / ECM  map

References
RTKs exist as inactive monomers; after binding to their ligands they form dimers and their intracellular domains are activated.
PMID:17496910

Modifications:
In compartment: Extracellular space
  1. PDGF family*@Extracellular space map
  2. PDGF family*|​hm2@Extracellular space map
Participates in complexes:
In compartment: Cytosol
  1. PDGF family*|​hm2:​PDGFR family*|​hm2@Cytosol map
Participates in reactions:
As Reactant or Product:
  1. PDGF family*@Extracellular space map → map PDGF family*|​hm2@Extracellular space map
  2. PDGF family*|​hm2@Extracellular space map + PDGFR family*@Cytosol map → map PDGF family*|​hm2:​PDGFR family*|​hm2@Cytosol map
  3. PDGF family*|​hm2:​PDGFR family*|​hm2@Cytosol map → map PDGFRB|​hm2|​active@Cytosol map
  4. PDGF family*|​hm2:​PDGFR family*|​hm2@Cytosol map → map PDGFRA|​hm2|​active@Cytosol map
  5. PDGF family*@Extracellular space map → map PDGFA@Extracellular space map
  6. PDGF family*@Extracellular space map → map PDGFB@Extracellular space map
  7. PDGF family*@Extracellular space map → map PDGFC@Extracellular space map
  8. PDGF family*@Extracellular space map → map PDGFD@Extracellular space map
As Catalyser:
  1. SHC1_p66_p52*@Cytosol map → map SHC1_p66_p52*|​Y_pho|​S_pho|​active@Cytosol map
  2. STAT5*@Cytosol map → map STAT5*|​pho|​active@Cytosol map