Protein STAT5* map

Identifiers
signal transducer and activator of transcription 5A
HUGO:STAT5A HGNC:11366 ENTREZ:6776 UNIPROT:P42229
signal transducer and activator of transcription 5B
HUGO:STAT5B HGNC:11367 ENTREZ:6777 UNIPROT:P51692
HUGO:STAT5A HUGO:STAT5B

Maps_Modules
HMC:ACTIVATING_INVASION_AND_METASTASIS
 EMT Senescence  map  / EMT_REGULATORS  map
 EMT Senescence  map  / MITOCHONDRIA_OXIDATIVE_STRESS  map
 EMT Senescence  map  / SENESCENCE  map
HMC:RESISTING_CELL_DEATH
 Regulated Cell Death  map  / ANTIOXIDANT_RESPONSE  map
 Regulated Cell Death  map  / APOPTOSIS  map
 Regulated Cell Death  map  / DEATH_RECEPTOR_PATHWAYS  map
 Regulated Cell Death  map  / RCD_GENES  map
HMC:AVOIDING_IMMUNE_DESTRUCTION
 Innate Immunity  map  / IMMUNOSTIMULATORY_CYTOKINE_PATHWAYS  map

References
PMID:28186502
 MACROPHAGE  map
 MDSC  map
 NATURAL_KILLER  map
CASCADE:IL15
CASCADE:IL21
CASCADE:IL2
CASCADE:CSF2
PMID:20406969, PMID:24091328, PMID:11867689
GM-CSF uniquely inhibited signal transducers and activators of transcription (STAT3) and promoted STAT5 activation, probably downstream of JAK2. STAT5ab(null/null) MDSC were rendered sensitive to sunitinib in the presence of GM-CSF in vitro.
PMID:24091328
G-CSF downregulates IRF8 expression via STAT3 and GM-CSF via STAT5. IRF8 inhibition provides immunosuppressive functions of MDSC.
PMID:20231889
Dcs Stat5-Tg mice are expressing ot surface high levels of MHC-II and costimulatory molecules such as CD80, CD86 and CD54 (ICAM1) and have increased level of I12 secretion (.)

STAT5*|​pho|​active@Nucleus

References
em_emtc_emtc_re1231( EMT Senescence  map ):
PMID:16079281
Phosphorylation of Sp-1 by ERK provokes an increase in the transcriptional activity of Sp1- dependent genes

STAT5*@Nucleus

Maps_Modules
HMC:RESISTING_CELL_DEATH
 Regulated Cell Death  map  / ANTIOXIDANT_RESPONSE  map
 Regulated Cell Death  map  / APOPTOSIS  map
 Regulated Cell Death  map  / DEATH_RECEPTOR_PATHWAYS  map
 Regulated Cell Death  map  / RCD_GENES  map

References
rc_re106( Regulated Cell Death  map ):
PMID:18208354
TP53 downregulates the activity of the MCL1 gene promoter in Hela and HEK293
mainly through an unkown mechanism. Critical importance of the -41 to +16 region that correspond to TATA-BP and other basal transcription factors binding
also through down regulation of Sp1
PMID:19808698
in MV4-11 cells, a human biphenotypic B myelomonocytic leukemia that displays FLT3-ITD mutation (constitutive FLT3 signalling), STAT5* siRNA prevents MCL1 expression
PMID:11160159
in large granular lymphocyte high STAT3 activity correlates with MCL1 expression, AG-490 JAK inhibitors induce apoptosis and decreases MCL1 expression.
in NIH3T3, upon v-src, STAT3 dependent expression of MCL1
rc_re190( Regulated Cell Death  map ):
PMID:19211554
in PC-3 human prostate cancer cell line by HIF, transactivation of the promoter (ChIP, EMSA, reporter gene assay)
PMID:10435632
in murine immortalized bone marrow-derived pro-B-cell BA/F3, by STAT5 upon IL3
PMID:10428780 AND PMID:10428030
in murine erythroleukemia HCD-57 cells, by STAT5 upon EPO (HGNC:3415) treatment
PMID:11756417
in UT-7/TPO human TPO-dependent megakaryocytic cell line, by STAT5 and NF-kappaB, upon TPO

STAT5*|​pho@INNATE_IMMUNE_CELL_Cytosol

References
in_re714( Innate Immunity  map ):
PMID:11964313
INFG upregulates expression components of TLR signaling: MD2 (LY96) and MYD88.
in_re717( Innate Immunity  map ):
PMID:12433365
INFG induces SOCS1 expression in macrophages.
PMID:10820262
Probably IFNG induces SOCS1 expressiov via IRF1 upregulation downstream of STAT1
PMID:18345002
TNF induces IRF1 expression both through TNFR1 and TNFR2.
TNF induced IFNB expression through IRF1

Modifications:
In compartment: Cytosol
  1. STAT5*@Cytosol map
  2. STAT5*|​pho|​active@Cytosol map
In compartment: INNATE_IMMUNE_CELL_Cytosol
  1. STAT5*@INNATE_IMMUNE_CELL_Cytosol map
  2. STAT5*|​pho@INNATE_IMMUNE_CELL_Cytosol map
In compartment: Nucleus
  1. STAT5*@Nucleus map
  2. STAT5*|​pho|​active@Nucleus map
Participates in complexes:
    Participates in reactions:
    As Reactant or Product:
    1. STAT family*@Cytosol map → map STAT5*@Cytosol map
    2. STAT5*@Cytosol map → map STAT5A@Cytosol map
    3. STAT5*@Cytosol map → map STAT5B@Cytosol map
    4. STAT5*@Cytosol map → map STAT5*|​pho|​active@Cytosol map
    5. STAT family*|​pho|​active@Cytosol map → map STAT5*|​pho|​active@Cytosol map
    6. STAT5*|​pho|​active@Cytosol map → map STAT5*|​pho|​active@Nucleus map
    7. STAT5*@INNATE_IMMUNE_CELL_Cytosol map → map STAT5*|​pho@INNATE_IMMUNE_CELL_Cytosol map
    As Catalyser:
    1. SP1@Nucleus map → map SP1|​pho|​active@Nucleus map
    2. gFOS@Nucleus map → map rFOS@Nucleus map
    3. ICAM1@INNATE_IMMUNE_CELL_Cytosol map → map ICAM1@INNATE_IMMUNE_CELL_Membrane map
    4. IL12*@INNATE_IMMUNE_CELL_Cytosol map → map IL12*@default map
    5. CD80@INNATE_IMMUNE_CELL_Cytosol map → map CD80@INNATE_IMMUNE_CELL_Membrane map
    6. CD86@INNATE_IMMUNE_CELL_Cytosol map → map CD86@INNATE_IMMUNE_CELL_Membrane map
    7. gCIITA@INNATE_IMMUNE_CELL_Cytosol map → map rCIITA@INNATE_IMMUNE_CELL_Cytosol map
    8. gMYD88@INNATE_IMMUNE_CELL_Cytosol map → map rMYD88@INNATE_IMMUNE_CELL_Cytosol map
    9. gIRF1@INNATE_IMMUNE_CELL_Cytosol map → map rIRF1@INNATE_IMMUNE_CELL_Cytosol map
    10. gIFNG@INNATE_IMMUNE_CELL_Cytosol map → map rIFNG@INNATE_IMMUNE_CELL_Cytosol map
    11. gIL2RA@INNATE_IMMUNE_CELL_Cytosol map → map rIL2RA@INNATE_IMMUNE_CELL_Cytosol map
    12. gIRF8@INNATE_IMMUNE_CELL_Cytosol map → map rIRF8@INNATE_IMMUNE_CELL_Cytosol map
    13. gPRF1@INNATE_IMMUNE_CELL_Cytosol map → map rPRF1@INNATE_IMMUNE_CELL_Cytosol map
    14. gMCL1@Nucleus map → map rMCL1@Nucleus map
    15. gBCL2-XL*@Nucleus map → map rBCL2-XL*@Nucleus map