Complex PDGF family*:PDGFR family* map
Complex composition:

  1. PDGFR family* map
  2. PDGF family* map

PDGF family*|​hm2:​PDGFR family*|​hm2@Cytosol

Identifiers
NAME:PDGF family*:PDGFR family*

Maps_Modules
HMC:ACTIVATING_INVASION_AND_METASTASIS
 EMT Senescence  map  / EMT_REGULATORS  map
 EMT Senescence  map  / ECM  map

References
em_emtc_emtc_re1272( EMT Senescence  map ):
PMID:17673906
Upon TGFB stimulation, the activated TGFBR1 recruits and directly phosphorylates SHC1 on tyrosine and serine.
TGFB-induced SHC1 phosphorylation induces SHC1 association with Grb2 and Sos
PMID:12767520
Upon IGF stimulation, the activated IGF1R recruits and directly phosphorylates SHC1, leading to cellular proliferation

Modifications:
Participates in complexes:
In compartment: Cytosol
  1. PDGF family*|​hm2:​PDGFR family*|​hm2@Cytosol map
Participates in reactions:
As Reactant or Product:
  1. PDGF family*|​hm2@Extracellular space map + PDGFR family*@Cytosol map → map PDGF family*|​hm2:​PDGFR family*|​hm2@Cytosol map
  2. PDGF family*|​hm2:​PDGFR family*|​hm2@Cytosol map → map PDGFRB|​hm2|​active@Cytosol map
  3. PDGF family*|​hm2:​PDGFR family*|​hm2@Cytosol map → map PDGFRA|​hm2|​active@Cytosol map
As Catalyser:
  1. SHC1_p66_p52*@Cytosol map → map SHC1_p66_p52*|​Y_pho|​S_pho|​active@Cytosol map
  2. STAT5*@Cytosol map → map STAT5*|​pho|​active@Cytosol map