Protein PDGFRA map

Identifiers
HGNC:8803
platelet-derived growth factor receptor alpha polypeptide
HUGO:PDGFRA HGNC:8803 ENTREZ:5156 UNIPROT:P16234

Maps_Modules
HMC:ACTIVATING_INVASION_AND_METASTASIS
 EMT Senescence  map  / EMT_REGULATORS  map
 EMT Senescence  map  / ECM  map

References
PMID:17145802
RTKs exist as inactive monomers; after binding to their ligands they form dimers and their intracellular domains are activated.
PMID:17496910

Modifications:
In compartment: Cytosol
  1. PDGFRA@Cytosol map
  2. PDGFRA|​hm2|​active@Cytosol map
Participates in complexes:
In compartment: Cytosol
  1. PDGFRA:​PDGFRB@Cytosol map
  2. PDGFB:​PDGFRA:​PDGFRB@Cytosol map
Participates in reactions:
As Reactant or Product:
  1. PDGFRA@Cytosol map + PDGFRB@Cytosol map → map PDGFRA:​PDGFRB@Cytosol map
  2. PDGFB@Extracellular Matrix map + PDGFRA:​PDGFRB@Cytosol map → map PDGFB:​PDGFRA:​PDGFRB@Cytosol map
  3. PDGFB:​PDGFRA:​PDGFRB@Cytosol map → map Lymphangiogenesis@Cytosol map
  4. PDGFR family*@Cytosol map → map PDGFRA@Cytosol map
  5. PDGF family*|​hm2:​PDGFR family*|​hm2@Cytosol map → map PDGFRA|​hm2|​active@Cytosol map
As Catalyser: