Identifiers
Rho GTPase activating protein 35
HUGO:ARHGAP35 hgnc_id:HGNC:4591 HGNC:4591 ENTREZ:2909 UNIPROT:Q9NRY4
HUGO:ARHGAP35 HGNC:4591 ENTREZ:2909 UNIPROT:Q9NRY4
Maps_Modules
HMC:TUMOR_PROMOTING_INFLAMMATION
HMC:ACTIVATING_INVASION_AND_METASTASIS
Cancer Associated Fibroblasts / MOTILITY
EMT Senescence / EMT_REGULATORS
EMT Senescence / CYTOSKELETON_POLARITY
References
CASCADE:CAV
CASCADE:INTEGRIN
PMID:17517963
Src is involved in activation of Rac (Servitja et al., 2003; Kawakatsu et al., 2005) and Cdc42 (Miyamoto et al., 2003; Tu et al., 2003; Fukuyama et al., 2005) and can inhibit Rho through activation of p190RhoGAP
PMID:22411312
ARHGAP35 (p190RhoGAP) inhibits RhoA.
Engagement of integrins triggers Src???dependent p190GAP
phosphorylation which when activated inhibits RhoA enabling Rac1 activation that
promotes lamellipodia formation, cell spreading and nascent focal adhesions.1
PMID:9819392
The GAP activity of ARHGAP35 (p190RhoGAP) is specific for RhoA inhibition.
PMID:8360177
RASA1 is a GAP for HRAS.
PMID:18829532
RasGAP actvity of RASA1 is reduced when associated with ARHGAP35 which is a specific GAP for RhoA
ARHGAP35 is tyrosine-phosphorylated.
The association of ARHGAP35 (p190) with RASA1 (p120) is promoted and stabilized by phosphorylation of p190 at Y1105 by PTK6..
→ ARHGAP35|pho@Cytosol
→ ARHGAP35|pho@Cytosol
→ ARHGAP35|pho@Cytosol
+ RASA1@Cytosol → ARHGAP35|pho:RASA1@Cytosol
→ ca_s813 + GDP@Cytosol