Identifiers
myeloid cell leukemia sequence 1 (BCL2-related)
HUGO:MCL1 HGNC:6943 ENTREZ:4170 UNIPROT:Q07820
HUGO:MCL1 HGNC:6943 ENTREZ:4170 UNIPROT:Q07820 GENECARDS:MCL1 KEGG:4170 ATLASONC:GC_MCL1 WIKI:MCL1
Maps_Modules
HMC:RESISTING_CELL_DEATH
Regulated Cell Death / ANTIOXIDANT_RESPONSE
Regulated Cell Death / APOPTOSIS
Regulated Cell Death / CASPASES
Regulated Cell Death / MOMP_REGULATION
HMC:EVADING_GROWTH_SUPPRESSORS
Survival / PI3K_AKT_MTOR
References
PMID:20540941
PMID:10454566
Maps_Modules
HMC:RESISTING_CELL_DEATH
Regulated Cell Death / ANTIOXIDANT_RESPONSE
Regulated Cell Death / APOPTOSIS
Regulated Cell Death / CASPASES
Regulated Cell Death / MOMP_REGULATION
References
rc_re106( Regulated Cell Death ):
PMID:18208354
TP53 downregulates the activity of the MCL1 gene promoter in Hela and HEK293
mainly through an unkown mechanism. Critical importance of the -41 to +16 region that correspond to TATA-BP and other basal transcription factors binding
also through down regulation of Sp1
PMID:19808698
in MV4-11 cells, a human biphenotypic B myelomonocytic leukemia that displays FLT3-ITD mutation (constitutive FLT3 signalling), STAT5* siRNA prevents MCL1 expression
PMID:11160159
in large granular lymphocyte high STAT3 activity correlates with MCL1 expression, AG-490 JAK inhibitors induce apoptosis and decreases MCL1 expression.
in NIH3T3, upon v-src, STAT3 dependent expression of MCL1
rc_re44( Regulated Cell Death ):
PMID:17404574
in human immortalized non malignant H69 cholangiocyte and malignant KMCH cholangiocarcinoma cell lines, MIR29B1 targets MCL1
PMID:19155302
MCL1 is a target of MIR101
PMID:19676043
in DBTRG-05MG human glioblastoma cell line, MCL1 targeted by MIR153
PMID:19654003
in H2009 human lung adenocarcinoma cells, MCL1 is a target of MIR133B
PMID:19966861
in Jurkat, HeLa, U937, glycolysis inhibition by 2deoxy glucose causes a specific block in transltion of MCL1, through a AMPK - TOR pathway
→ rMCL1@Nucleus
→ MCL1@Mitochondrial inner membrane
→ rMCL1@Nucleus