Protein HRK map

Identifiers
harakiri, BCL2 interacting protein (contains only BH3 domain)
HUGO:HRK HGNC:5185 ENTREZ:8739 UNIPROT:O00198

Maps_Modules
HMC:RESISTING_CELL_DEATH
 Regulated Cell Death  map  / APOPTOSIS  map
 Regulated Cell Death  map  / CASPASES  map
 Regulated Cell Death  map  / MOMP_REGULATION  map
 Regulated Cell Death  map  / RCD_GENES  map

HRK@Mitochondrial inner membrane

Maps_Modules
HMC:RESISTING_CELL_DEATH
 Regulated Cell Death  map  / APOPTOSIS  map
 Regulated Cell Death  map  / CASPASES  map
 Regulated Cell Death  map  / MOMP_REGULATION  map
 Regulated Cell Death  map  / RCD_GENES  map

References
rc_re613( Regulated Cell Death  map ):
PMID:15031724
Y2H by Y2H and coIP
a p32 mutant defective for interaction with HRK fails to target HRK to mitochondria and protects against HRK mediated apoptosis
p32 proposed to anchor HRK to the mitochondria
rc_re606( Regulated Cell Death  map ):
PMID:9130713
PMID:10075695
in 293T, IP
rc_re612( Regulated Cell Death  map ):
Y2H with human cDNA

HRK@Cytosol

Maps_Modules
HMC:RESISTING_CELL_DEATH
 Regulated Cell Death  map  / APOPTOSIS  map
 Regulated Cell Death  map  / CASPASES  map
 Regulated Cell Death  map  / MOMP_REGULATION  map
 Regulated Cell Death  map  / RCD_GENES  map

References
rc_re613( Regulated Cell Death  map ):
PMID:15031724
Y2H by Y2H and coIP
a p32 mutant defective for interaction with HRK fails to target HRK to mitochondria and protects against HRK mediated apoptosis
p32 proposed to anchor HRK to the mitochondria

Modifications:
In compartment: Cytosol
  1. HRK@Cytosol map
In compartment: Mitochondrial inner membrane
  1. HRK@Mitochondrial inner membrane map
Participates in complexes:
In compartment: Mitochondrial inner membrane
  1. BCL2:​HRK@Mitochondrial inner membrane map
  2. BCL2-XL*:​HRK@Mitochondrial inner membrane map
  3. HRK:​MCL1|​S159_unk@Mitochondrial inner membrane map
Participates in reactions:
As Reactant or Product:
  1. HRK@Cytosol map → map HRK@Mitochondrial inner membrane map
  2. rHRK@Nucleus map → map HRK@Cytosol map
  3. HRK@Mitochondrial inner membrane map + BCL2-XL*@Mitochondrial inner membrane map → map BCL2-XL*:​HRK@Mitochondrial inner membrane map
  4. HRK@Mitochondrial inner membrane map + BCL2|​pho@Mitochondrial inner membrane map → map BCL2:​HRK@Mitochondrial inner membrane map
  5. HRK@Mitochondrial inner membrane map + MCL1|​S159_unk@Mitochondrial inner membrane map → map HRK:​MCL1|​S159_unk@Mitochondrial inner membrane map
  6. HRK@Cytosol map → map HRK@Mitochondrial inner membrane map
As Catalyser: