→ MCL1|S159_pho|ubi@Mitochondrial inner membrane References
PMID:15989957
in Hela MCL1 ubiquitination mainly on lysines 136, 194, and 197
purification of MCL1 E3 ubiquitin ligase from the cytosol of Hela cells
in vitro reconstitution of the system
HUWE1 KD
PMID:16543145
suggest that HUWE1 preferentially target S159 phosphorylated MCL1 for polyubiquitination
PMID:16213503
HUWE1 is a BH3 domain protein - competition HUWE1 / Bim for binding to MCL1