Protein BAK1 map

Identifiers
BCL2-antagonist/killer 1
HUGO:BAK1, HGNC:949, ENTREZ:578, UNIPROT:Q16611, GENECARDS:GC06M033489
HUGO:BAK1 HGNC:949 ENTREZ:578 UNIPROT:Q16611

Maps_Modules
HMC:ACTIVATING_INVASION_AND_METASTASIS
 EMT Senescence  map  / EMT_REGULATORS  map
 EMT Senescence  map  / MITOCHONDRIA_OXIDATIVE_STRESS  map
HMC:RESISTING_CELL_DEATH
 Regulated Cell Death  map  / APOPTOSIS  map
 Regulated Cell Death  map  / CASPASES  map
 Regulated Cell Death  map  / MOMP_REGULATION  map
 Regulated Cell Death  map  / NECROPTOSIS  map
 Regulated Cell Death  map  / ER_STRESS  map

References
PMID:22039431
The Bcl2 family proteins regulate and mediate the mitochondrial outer membrane permeabilization, a crucial event in the mitochondrial pathway of apoptosis in vertebrates.
The regulation of apoptosis is governed largely by interactions between the pro-survival and pro-death members of the Bcl2 protein family.
Some members of this family (e.g., Bax, Bak, and Bid: pro-apoptotic proteins) promote apoptosis, while others such as BCL2, BCL2L1, BCL2L2 (anti-apoptotic proteins) work against programmed cell death.
The BCL2 family proteins are characterized by regions of specific sequence homology named as BCL2 homology (BH) motifs that number from 1 to 4 and are critical for function.
Especially a helical BH3 motif of pro-apoptotic proteins occupy and form strong interactions with hydrophobic groove of anti-apoptotic BCL2 family proteins which leads to the activation of the essential death mediators Bax and Bak, thereby committing cells to apoptosis
PMID:23850759
PMID:23430059
Bax and Bak positively modulate the amplitude of IRE1asignaling by interacting at the ER with the cytoplasmic domains of IRE1a resulting in increased XBP1s and JNK phosphorylation

BAK1@Mitochondria

References
em_emtc_emtc_re431( EMT Senescence  map ):
PMID:22039431
The Bcl2 family proteins regulate and mediate the mitochondrial outer membrane permeabilization, a crucial event in the mitochondrial pathway of apoptosis in vertebrates.
The regulation of apoptosis is governed largely by interactions between the pro-survival and pro-death members of the Bcl2 protein family.
Some members of this family (e.g., Bax, Bak, and Bid: pro-apoptotic protines) promote apoptosis, while others such as BCL2, BCL2L1, BCL2L2 (anti-apoptotic protines)work against programmed cell death.
The BCL2 family proteins are characterized by regions of specific sequence homology named as BCL2 homology (BH) motifs that number from 1 to 4 and are critical for function.
Especially a helical BH3 motif of pro-apoptotic proteins occupy and form strong interactions with hydrophobic groove of anti-apoptotic BCL2 family proteins which leads to the activation of the essential death mediators Bax and Bak, thereby committing cells to apoptosis:
em_emtc_emtc_re437( EMT Senescence  map ):
PMID:15077116
p53 has a direct signalling role at mitochondria in the induction of apoptosis
p53 interacts with the pro- apoptotic mitochondrial membrane protein Bak. Interaction of p53 with Bak causes oligomerization and thus activation of Bak and release of cytochrome c from mitochondria.
Formation of the p53???Bak complex coincides with loss of an interaction between Bak and the anti-apoptotic Bcl2-family member Mcl1.
These results are consistent with a model in which p53 and Mcl1 have opposing effects on mitochondrial apoptosis by interacting with, and modulating the activity of, the death effector Bak.

BAK1@Mitochondrial inner membrane

Maps_Modules
HMC:RESISTING_CELL_DEATH
 Regulated Cell Death  map  / APOPTOSIS  map
 Regulated Cell Death  map  / CASPASES  map
 Regulated Cell Death  map  / MOMP_REGULATION  map
 Regulated Cell Death  map  / NECROPTOSIS  map

Modifications:
In compartment: Endopasmic Reticulum
  1. BAK1@Endopasmic Reticulum map
In compartment: Mitochondria
  1. BAK1@Mitochondria map
In compartment: Mitochondrial inner membrane
  1. BAK1@Mitochondrial inner membrane map
Participates in complexes:
In compartment: Endopasmic Reticulum
  1. BAK1:​BCL2@Endopasmic Reticulum map
  2. BAK1:​TMBIM3@Endopasmic Reticulum map
  3. BAK1:​BCL2-XL*@Endopasmic Reticulum map
  4. BAK1:​IRE1-alpha*@Endopasmic Reticulum map
In compartment: Mitochondria
  1. BAK1:​BCL2@Mitochondria map
  2. BAK1:​p53*@Mitochondria map
  3. BAK1:​BCL2-XL*@Mitochondria map
In compartment: Mitochondrial inner membrane
  1. BAK1:​VDAC2@Mitochondrial inner membrane map
  2. BAK1:​IGFBP1@Mitochondrial inner membrane map
  3. BAK1:​MCL1|​S159_unk@Mitochondrial inner membrane map
Participates in reactions:
As Reactant or Product:
  1. BCL2@Mitochondria map + BAK1@Mitochondria map → map BAK1:​BCL2@Mitochondria map
  2. BCL2-XL*@Mitochondria map + BAK1@Mitochondria map → map BAK1:​BCL2-XL*@Mitochondria map
  3. p53*@Mitochondria map + BAK1@Mitochondria map → map BAK1:​p53*@Mitochondria map
  4. BAK1:​p53*@Mitochondria map → map Apoptosis@Cytosol map
  5. BAK1@Mitochondrial inner membrane map → map rc_s11
  6. VDAC2@Mitochondrial inner membrane map + BAK1@Mitochondrial inner membrane map → map BAK1:​VDAC2@Mitochondrial inner membrane map
  7. rBAK1@Nucleus map → map BAK1@Mitochondrial inner membrane map
  8. BAK1@Mitochondrial inner membrane map + IGFBP1@Cytosol map → map BAK1:​IGFBP1@Mitochondrial inner membrane map
  9. MCL1|​S159_unk@Mitochondrial inner membrane map + BAK1@Mitochondrial inner membrane map → map BAK1:​MCL1|​S159_unk@Mitochondrial inner membrane map
  10. BCL2@Endopasmic Reticulum map + BAK1@Endopasmic Reticulum map → map BAK1:​BCL2@Endopasmic Reticulum map
  11. BCL2-XL*@Endopasmic Reticulum map + BAK1@Endopasmic Reticulum map → map BAK1:​BCL2-XL*@Endopasmic Reticulum map
  12. IRE1-alpha*@Endopasmic Reticulum map + BAK1@Endopasmic Reticulum map → map BAK1:​IRE1-alpha*@Endopasmic Reticulum map
  13. TMBIM3@Endopasmic Reticulum map + BAK1@Endopasmic Reticulum map → map BAK1:​TMBIM3@Endopasmic Reticulum map
As Catalyser:
  1. IRE1-alpha*:​Unfolded protein*@Endopasmic Reticulum map + TRAF2@Cytosol map → map MCL1|​pho|​hm2:​TRAF2:​Unfolded protein*@Endopasmic Reticulum map