Protein SOCS1 map

Identifiers
HUGO:SOCS1

Maps_Modules
MODULE:MACROPHAGE
MODULE:IMMUNOSTIMULATORY_CYTOKINE_PATHWAYS

References
SOCS-1 decreases IFNG signaling via inhiviting the catalytic activity of JAKs.
PMID:12811837
SOCS-1 overexpression resulted in a nearly complete loss of IFNG responsiveness in macrophages.
PMID:10485906
SOCS1 inhibits STAT6 activation downstream of IFNG and downregulates IL4 signaling pathway.
PMID:12193701
INFG upregulates TNFR1 and RIPK1 expression, probably via JAK/STAT1 pathway
because this expression is inhibited in presense of SOCS1.

SOCS1@Cytosol

Identifiers

Maps_Modules

References

Modifications:
In compartment: Cytosol
  1. SOCS1@Cytosol map
Participates in complexes:
    Participates in reactions:
    As Reactant or Product:
    1. rSOCS1@Cytosol map → map SOCS1@Cytosol map
    As Catalyser:
    1. STAT6@Cytosol map → map STAT6|​pho|​active@Cytosol map
    2. JAK2@Cytosol map + JAK1@Cytosol map + IFNGR1:​IFNGR2@Membrane map + IFNG|​hm2@default map → map IFNGR1|​pho:​IFNGR2:​IFNG|​hm2:​JAK1:​JAK2@Membrane map
    3. gTNFR1*@Cytosol map → map rTNFR1*@Cytosol map
    4. gRIPK1@Cytosol map → map rRIPK1@Cytosol map