PALS1*

Protein PALS1*

Identifiers
membrane protein, palmitoylated 5 (MAGUK p55 subfamily member 5)
HUGO:MPP5, HGNC:18669, ENTREZ:64398, UNIPROT:Q8NI35, GENECARDS:GC14P067708????

Maps_Modules
HMC:ACTIVATING_INVASION_AND_METASTASIS
EMT Senescence / EMT_REGULATORS
EMT Senescence / CELL_CELL_ADHESIONS
EMT Senescence / TIGHT_JUNCTIONS
EMT Senescence / CYTOSKELETON_POLARITY

PALS1*@Cytosol

Maps_Modules
HMC:ACTIVATING_INVASION_AND_METASTASIS
EMT Senescence / EMT_REGULATORS
EMT Senescence / CELL_CELL_ADHESIONS
EMT Senescence / TIGHT_JUNCTIONS
EMT Senescence / CYTOSKELETON_POLARITY

References
PMID:11927608
PALS1 is an adapter linking Crumbs and PATJ*
PALS1 contains two L27 domains, 1 PDZ domain, 1 SH3 domain, 1 inactive Guanylate kinase domain
Interaction PALS1 -LIN7 via the C-terminal L27 domain of PALS1
em_emtc_emtc_re90( EMT Senescence ):
PMID:17012742
Without LIN7, PALS1 is instable and degraded. Binding of LIN7 to PALS1 stabilizes the latter.
Loss of Lin7 correlates with the lost of PALS1 expression (translation) but the level of mRNA-PALS1 is not changed (transcription).
The effect is rescued by exogenous LIN7 containing L27 but not PGZ domain
em_emtc_emtc_re114( EMT Senescence ):
Without LIN7, PALS1 is instable and degraded
Binidng of LIN7 to PALS1 stabilizes the latter
Loss of Lin7 correlates with the lost of PALS1 expression
em_emtc_emtc_re33( EMT Senescence ):
PMID:18005931
PMID:14718565
Loss of PALS1 rusuls in concomitant loss of PATJ expression but has no effect on CRB3 expression or distribution
It is not yet known whether the absence of PALS1 affects PATJ expression via transcription, translation or stability of the protein.
em_emtc_emtc_re95( EMT Senescence ):
PMID:8365569
PMID:11740559
PMID:11740560
CRB3 and PALS1* in the same pathway
PALS1* binds to CRB3 via its PDZ domain

Modifications:
In compartment: Cytosol

PALS1*@Cytosol

Participates in complexes:
In compartment: Cytosol

Participates in reactions:
As Reactant or Product:

As Catalyser:

rPATJ*@Nucleus → PATJ*@Cytosol