Reaction translation em_emtc_emtc_re90 map

rPALS1*@Nucleus map → PALS1*@Cytosol map

Reaction regulators:
Physical_stimulation
  1. LIN7C@Cytosol map


Maps_Modules
HMC:ACTIVATING_INVASION_AND_METASTASIS
 EMT Senescence  map  / EMT_REGULATORS  map
 EMT Senescence  map  / CELL_CELL_ADHESIONS  map
 EMT Senescence  map  / TIGHT_JUNCTIONS  map
 EMT Senescence  map  / CYTOSKELETON_POLARITY  map

References
PMID:17012742
Without LIN7, PALS1 is instable and degraded. Binding of LIN7 to PALS1 stabilizes the latter.
Loss of Lin7 correlates with the lost of PALS1 expression (translation) but the level of mRNA-PALS1 is not changed (transcription).
The effect is rescued by exogenous LIN7 containing L27 but not PGZ domain