Protein PATJ* map

Identifiers
InaD-like (Drosophila)
HUGO:INADL, HGNC:28881, ENTREZ:10207, UNIPROT:Q8NI35, GENECARDS:GC01P062208??

Maps_Modules
HMC:ACTIVATING_INVASION_AND_METASTASIS
 EMT Senescence  map  / EMT_REGULATORS  map
 EMT Senescence  map  / CYTOSKELETON_POLARITY  map

References
PMID:17486063
PATJ* is repressed by ZEB1
PMID:10102271
PATJ* is a component of the Crb complex. The L27 domain of PATJ* binds to the L27 domain of PALS1*
PMID:22881460
Apical recuritment if PATJ* depends on the CRB3/PALS1* complex
PMID:18005931
PATJ contains one L27 domain (interacting with the N-ter L27 of PALS1) and has up to 10 PDZ domains.
The 6th PDZ interacts with ZO3 and the 8th interacts with Claudin1.
The ZO3 cytoplasmic protein is linked to tight junctions via its association with Occludin. Occludin and Claudin1 are transmembrane proteins
PMID:16129888
PATJ expression affects the localization of ZO1, ZO3, Occludin, CRB3 and PALS1
PATJ provides a link between the lateral (Occludin and ZO3) and apical (PALS1 and CRB3) components of tight junctions and stabilizes the CRB3 complex

PATJ*@Cytosol

Maps_Modules
HMC:ACTIVATING_INVASION_AND_METASTASIS
 EMT Senescence  map  / EMT_REGULATORS  map
 EMT Senescence  map  / CYTOSKELETON_POLARITY  map

References
PMID:17486063
PATJ* is repressed by ZEB1
PMID:10102271
PATJ* is a component of the Crb complex. The L27 domain of PATJ* binds to the L27 domain of PALS1*
PMID:22881460
Apical recuritment if PATJ* depends on the CRB3/PALS1* complex
PMID:18005931
PATJ contains one L27 domain (interacting with the N-ter L27 of PALS1) and has up to 10 PDZ domains.
The 6th PDZ interacts with ZO3 and the 8th interacts with Claudin1.
The ZO3 cytoplasmic protein is linked to tight junctions via its association with Occludin. Occludin and Claudin1 are transmembrane proteins
PMID:16129888
PATJ expression affects the localization of ZO1, ZO3, Occludin, CRB3 and PALS1
PATJ provides a link between the lateral (Occludin and ZO3) and apical (PALS1 and CRB3) components of tight junctions and stabilizes the CRB3 complex
em_emtc_emtc_re33( EMT Senescence  map ):
PMID:14718565
Loss of PALS1 rusuls in concomitant loss of PATJ expression but has no effect on CRB3 expression or distribution
It is not yet known whether the absence of PALS1 affects PATJ expression via transcription, translation or stability of the protein.
em_emtc_emtc_re96( EMT Senescence  map ):
PMID:11927608
PALS1 contains two L27 domains, 1 PDZ domain, 1 SH3 domain, 1 inactive Guanylate kinase domain
Interaction PALS1-LIN7 via the C-terminal L27 domain of PALS1
PMID:10871881
LIN7 contains one L27 domain, 1 PDZ domain
PMID:18177979
Lin7 is a component of the Crumbs complex in Drosophila epithelia and photoreceptor cells
PMID:2288140
Apical recuritment of PATJ* and LIN7 depends on the CRB3/PALS1* complex

Modifications:
In compartment: Cytosol
  1. PATJ*@Cytosol map
Participates in complexes:
In compartment: Cytosol
  1. CRB3:​LIN7C:​PALS1*:​PATJ*@Cytosol map
Participates in reactions:
As Reactant or Product:
  1. CRB3:​LIN7C:​PALS1*:​PATJ*@Cytosol map → map PALS1*@Cytosol map
  2. PATJ*@Cytosol map → map CRB3:​LIN7C:​PALS1*:​PATJ*@Cytosol map
  3. rPATJ*@Nucleus map → map PATJ*@Cytosol map
  4. CRB3:​LIN7C:​PALS1*:​PATJ*@Cytosol map → map Epithelial polarity@Nucleus map
  5. CRB3:​LIN7C:​PALS1*:​PATJ*@Cytosol map → map Tight junctions@Neighbouring Cell map
  6. PATJ*@Cytosol map + CRB3:​PALS1*@Cytosol map + LIN7C@Cytosol map → map CRB3:​LIN7C:​PALS1*:​PATJ*@Cytosol map
As Catalyser: