Identifiers
crumbs homolog 3 (Drosophila)
HUGO:CRB3, HGNC:20237, ENTREZ:92359, UNIPROT:Q9BUF7, GENECARDS:GC19P006414??

Maps_Modules
HMC:ACTIVATING_INVASION_AND_METASTASIS
 EMT Senescence   / EMT_REGULATORS 
 EMT Senescence   / CYTOSKELETON_POLARITY 

References
PMID:22881460
CRB3 is the only transmembrane protein among apical polarity regulators
PMID:2344615
Link between Drosophila apical membrane Crb and epithelia organization

Maps_Modules
HMC:ACTIVATING_INVASION_AND_METASTASIS
 EMT Senescence   / EMT_REGULATORS 
 EMT Senescence   / CYTOSKELETON_POLARITY 

References
PMID:22881460
CRB3 is the only transmembrane protein among apical polarity regulators
PMID:2344615
Link between Drosophila apical membrane Crb and epithelia organization
em_emtc_emtc_re113( EMT Senescence  ):
PMID:2288140
PMID:8365569
Without PALS1 (Sdt in Drosophila), CRB is delivered to the apical plasma membrane but rapidly endocytosed and degraded
The complex PALS1-CRB hence stabilizes CRB
em_emtc_emtc_re95( EMT Senescence  ):
PMID:18005931
PMID:11740559
PMID:11740560
CRB3 and PALS1* in the same pathway
PALS1* binds to CRB3 via its PDZ domain

1. CRB3@Cytosol

1. CRB3:​PALS1*@Cytosol
2. CRB3:​LIN7C:​PALS1*:​PATJ*@Cytosol

1. CRB3:​PALS1*@Cytosol → CRB3@Cytosol
2. CRB3:​LIN7C:​PALS1*:​PATJ*@Cytosol → PALS1*@Cytosol
3. PATJ*@Cytosol → CRB3:​LIN7C:​PALS1*:​PATJ*@Cytosol
4. rCRB3@Nucleus → CRB3@Cytosol
5. CRB3:​LIN7C:​PALS1*:​PATJ*@Cytosol → Epithelial polarity@Nucleus
6. CRB3:​LIN7C:​PALS1*:​PATJ*@Cytosol → Tight junctions@Neighbouring Cell
7. CRB3@Cytosol → degraded
8. CRB3@Cytosol → degraded
9. CRB3@Cytosol + PALS1*@Cytosol → CRB3:​PALS1*@Cytosol
10. PATJ*@Cytosol + CRB3:​PALS1*@Cytosol + LIN7C@Cytosol → CRB3:​LIN7C:​PALS1*:​PATJ*@Cytosol