Identifiers
membrane protein, palmitoylated 5 (MAGUK p55 subfamily member 5)
HUGO:MPP5, HGNC:18669, ENTREZ:64398, GENECARDS:GC14P067708????
Maps_Modules
HMC:ACTIVATING_INVASION_AND_METASTASIS
EMT Senescence / EMT_REGULATORS
EMT Senescence / CELL_CELL_ADHESIONS
EMT Senescence / TIGHT_JUNCTIONS
Maps_Modules
HMC:ACTIVATING_INVASION_AND_METASTASIS
EMT Senescence / EMT_REGULATORS
EMT Senescence / CELL_CELL_ADHESIONS
EMT Senescence / TIGHT_JUNCTIONS
References
em_emtc_emtc_re89( EMT Senescence ):
PMID:17012742
Knock down of LIN7 results in loss of expression of PATJ*
em_emtc_emtc_re90( EMT Senescence ):
Without LIN7, PALS1 is instable and degraded. Binding of LIN7 to PALS1 stabilizes the latter.
Loss of Lin7 correlates with the lost of PALS1 expression (translation) but the level of mRNA-PALS1 is not changed (transcription).
The effect is rescued by exogenous LIN7 containing L27 but not PGZ domain