Phenotype Tight junctions map
Tight junctions@Neighbouring Cell

Maps_Modules
HMC:ACTIVATING_INVASION_AND_METASTASIS
 EMT Senescence  map  / EMT_REGULATORS  map
 EMT Senescence  map  / CYTOSKELETON_POLARITY  map
 EMT Senescence  map  / CELL_CELL_ADHESIONS  map
 EMT Senescence  map  / CELL_MATRIX_ADHESIONS  map
 EMT Senescence  map  / ECM  map
 EMT Senescence  map  / TIGHT_JUNCTIONS  map
 EMT Senescence  map  / GAP_JUNCTIONS  map
 EMT Senescence  map  / ADHERENS_JUNCTIONS  map
 EMT Senescence  map  / DESMOSOMES  map

References
PMID:15151915
Tight cell juntions serve as a physical barrier to prevent solutes and water from passing freely through the paracellular space between epithelial or endothelial cell sheets.
Multicellular organisms are separated from the external environment by a layer of epithelial cells
The integrity of these epithelial cells is maintained by intercellular junctional complexes (tight junctions, adherens junctions, and desmosomes,
whereas gap junctions provide for intercellular communication.
em_emtc_emtc_re346( EMT Senescence  map ):
PMID:22949611
Signaling molecules act directly on polarity proteins, bypassing transcription factors such as Snail and Zeb1:
TGFBR1 binds to the tight junction protein Occludin and locally assembles into a complex containing Par6.
Activated TGFBR2 phosphorylates Par6, which binds to Smurf1 and causes RhoA ubiquitylation and the dissolution of junctions.
em_emtc_emtc_re653( EMT Senescence  map ):
GJB1 is so-called Connexin 32 or Cx32
PMID:11978007
Cx32 Formation and / or Cx32-Mediated Intercellular Communication Induces Expression and Function of Tight Junctions in Hepatocytic Cell Line
PMID:17568974
Connexins induce and maintain tight junctions in epithelial cells.
em_emtc_emtc_re656( EMT Senescence  map ):
PMID:15292177
In mouse epithelial cells lacking any ZO-1 expression, there is retarded tight junction formation.
This phenotype was rescued by exogenous expression of ZO-1, but not by ZO-2, suggesting that these proteins are not functionally redundant
PMID:15980428

Tight junctions@Cytoplasm

References
s_wnc4_re33:( Survival  map ) PMID:18285450

Modifications:
In compartment: Cytoplasm
  1. Tight junctions@Cytoplasm map
In compartment: Neighbouring Cell
  1. Tight junctions@Neighbouring Cell map
Participates in complexes:
    Participates in reactions:
    As Reactant or Product:
    1. degraded → map Tight junctions@Neighbouring Cell map
    2. CRB3:​LIN7C:​PALS1*:​PATJ*@Cytosol map → map Tight junctions@Neighbouring Cell map
    3. em_emtc_emtc_s2905 → map Tight junctions@Neighbouring Cell map
    4. JAM2:​JAM3@Neighbouring Cell map → map Tight junctions@Neighbouring Cell map
    5. em_s2533 → map Tight junctions@Neighbouring Cell map
    6. Claudin1*:​Occludin*@Neighbouring Cell map → map Tight junctions@Neighbouring Cell map
    7. Claudin2*:​Occludin*@Neighbouring Cell map → map Tight junctions@Neighbouring Cell map
    8. em_s2505 → map Tight junctions@Neighbouring Cell map
    9. em_s2506 → map Tight junctions@Neighbouring Cell map
    10. em_s2532 → map Tight junctions@Neighbouring Cell map
    11. Claudin1*:​Claudin3*@Neighbouring Cell map → map Tight junctions@Neighbouring Cell map
    12. Claudin2*:​Claudin3*@Neighbouring Cell map → map Tight junctions@Neighbouring Cell map
    13. Claudin3*:​Claudin5*@Neighbouring Cell map → map Tight junctions@Neighbouring Cell map
    14. em_s2507 → map Tight junctions@Neighbouring Cell map
    15. em_s2508 → map Tight junctions@Neighbouring Cell map
    16. em_emtc_emtc_s2439 → map Tight junctions@Neighbouring Cell map
    17. GJB1:​Occludin*@Cytosol map → map Tight junctions@Neighbouring Cell map
    18. GJB1:​ZO1_2*@Cytosol map → map Tight junctions@Neighbouring Cell map
    19. GJA1:​ZO1*@Cytosol map → map Tight junctions@Neighbouring Cell map
    20. Tight junctions@Neighbouring Cell map → map Cell-cell adhesions@Neighbouring Cell map
    21. G_alpha__sub_12_endsub_*@Cytoplasm map → map Tight junctions@Cytoplasm map
    As Catalyser: