Identifiers
lin-7 homolog C (C. elegans)
HUGO:LIN7C, HGNC:17789, ENTREZ:55327, UNIPROT:Q9NUP9, GENECARDS:GC11M027472????

Maps_Modules
HMC:ACTIVATING_INVASION_AND_METASTASIS
 EMT Senescence   / EMT_REGULATORS 
 EMT Senescence   / CYTOSKELETON_POLARITY 

References
PMID:9753323
Heterotrimeric complex Lin2-Lin7-Lin10 (C. elegans)
PMID:9822620
human lin10 contains 2 PDZ domains
human lin10 interacts with mammalian lin2 (CASK)
mammalian lin7 interacts with mammalian lin2 (CASK)
heterotrimeric complex Lin2-lin7-Lin10 in mouse brain
PMID:9753324
Trimeric complex Lin2-Lin7-Lin10 in brain.
Each protein contains PDZ domains-not involved in complex formation
PMID:10871881
LIN2(CASK) contains two L27 domains, 1 PDZ domain, 1 SH3 domain, 1 inactive Guanylate Kinase domain
LIN7 contains one L27 domain, 1 PDZ domain
Interaction LIN2-LIN7 via L27 domain

Maps_Modules
HMC:ACTIVATING_INVASION_AND_METASTASIS
 EMT Senescence   / EMT_REGULATORS 
 EMT Senescence   / CYTOSKELETON_POLARITY 

References
PMID:9753323
Heterotrimeric complex Lin2-Lin7-Lin10 (C. elegans)
PMID:9822620
human lin10 contains 2 PDZ domains
human lin10 interacts with mammalian lin2 (CASK)
mammalian lin7 interacts with mammalian lin2 (CASK)
heterotrimeric complex Lin2-lin7-Lin10 in mouse brain
PMID:9753324
Trimeric complex Lin2-Lin7-Lin10 in brain.
Each protein contains PDZ domains-not involved in complex formation
PMID:10871881
LIN2(CASK) contains two L27 domains, 1 PDZ domain, 1 SH3 domain, 1 inactive Guanylate Kinase domain
LIN7 contains one L27 domain, 1 PDZ domain
Interaction LIN2-LIN7 via L27 domain
em_emtc_emtc_re90( EMT Senescence  ):
PMID:17012742
Without LIN7, PALS1 is instable and degraded. Binding of LIN7 to PALS1 stabilizes the latter.
Loss of Lin7 correlates with the lost of PALS1 expression (translation) but the level of mRNA-PALS1 is not changed (transcription).
The effect is rescued by exogenous LIN7 containing L27 but not PGZ domain
em_emtc_emtc_re96( EMT Senescence  ):
PMID:10102271
PATJ* is a component of the Crb complex. The L27 domain of PATJ* binds to the L27 domain of PALS1*
PMID:11927608
PALS1 contains two L27 domains, 1 PDZ domain, 1 SH3 domain, 1 inactive Guanylate kinase domain
Interaction PALS1-LIN7 via the C-terminal L27 domain of PALS1
PMID:18177979
Lin7 is a component of the Crumbs complex in Drosophila epithelia and photoreceptor cells
PMID:2288140
Apical recuritment of PATJ* and LIN7 depends on the CRB3/PALS1* complex

1. LIN7C@Cytosol

1. LIN10*:​LIN2*:​LIN7C@Cytosol
2. CRB3:​LIN7C:​PALS1*:​PATJ*@Cytosol

1. rLIN7C@Nucleus → LIN7C@Cytosol
2. LIN2*@Cytosol + LIN7C@Cytosol + LIN10*@Cytosol → LIN10*:​LIN2*:​LIN7C@Cytosol
3. CRB3:​LIN7C:​PALS1*:​PATJ*@Cytosol → PALS1*@Cytosol
4. PATJ*@Cytosol → CRB3:​LIN7C:​PALS1*:​PATJ*@Cytosol
5. CRB3:​LIN7C:​PALS1*:​PATJ*@Cytosol → Epithelial polarity@Nucleus
6. CRB3:​LIN7C:​PALS1*:​PATJ*@Cytosol → Tight junctions@Neighbouring Cell
7. PATJ*@Cytosol + CRB3:​PALS1*@Cytosol + LIN7C@Cytosol → CRB3:​LIN7C:​PALS1*:​PATJ*@Cytosol

1. rPALS1*@Nucleus → PALS1*@Cytosol