CRB3:LIN7C:PALS1*:PATJ*

Complex CRB3:LIN7C:PALS1*:PATJ*

Complex composition:

CRB3:LIN7C:PALS1*:PATJ*@Cytosol

Identifiers
NAME:CRB3:LIN7C:PALS1*:PATJ*

Maps_Modules
HMC:ACTIVATING_INVASION_AND_METASTASIS
EMT Senescence / EMT_REGULATORS
EMT Senescence / CYTOSKELETON_POLARITY

References
PMID:10102271
PATJ* is a component of the Crb complex. The L27 domain of PATJ* binds to the L27 domain of PALS1*
PMID:18177979
Lin7 is a component of the Crumbs complex in Drosophila epithelia and photoreceptor cells
PMID:2288140
Apical recuritment of PATJ* and LIN7 depends on the CRB3/PALS1* complex
em_emtc_emtc_re96( EMT Senescence ):
PMID:11927608
PALS1 contains two L27 domains, 1 PDZ domain, 1 SH3 domain, 1 inactive Guanylate kinase domain
Interaction PALS1-LIN7 via the C-terminal L27 domain of PALS1
PMID:10871881
LIN7 contains one L27 domain, 1 PDZ domain
em_emtc_emtc_re117( EMT Senescence ):
PMID:16129888
PATJ expression affects the localization of ZO1, ZO3, Occludin, CRB3 and PALS1
PATJ provides a link between the lateral (Occludin and ZO3) and apical (PALS1 and CRB3) components of tight junctions and stabilizes the CRB3 complex
em_emtc_emtc_re114( EMT Senescence ):
PMID:17012742
Without LIN7, PALS1 is instable and degraded
Binidng of LIN7 to PALS1 stabilizes the latter
Loss of Lin7 correlates with the lost of PALS1 expression
The effect is rescued by exogenous LIN7 containing L27 but not PGZ domain

Modifications:
Participates in complexes:
In compartment: Cytosol

CRB3:LIN7C:PALS1*:PATJ*@Cytosol

Participates in reactions:
As Reactant or Product:

As Catalyser: