Protein APC2* map

Identifiers
anaphase promoting complex subunit 2
HUGO:ANAPC2, HGNC:19989, ENTREZ:29882, UNIPROT:Q9UJX6
HUGO:ANAPC2 HGNC:19989 ENTREZ:29882 UNIPROT:Q9UJX6 GENECARDS:ANAPC2 REACTOME:84976 KEGG:29882 ATLASONC:GC_ANAPC2 WIKI:ANAPC2
axin 1
HUGO:AXIN1 HGNC:903 ENTREZ:8312 UNIPROT:O15169 GENECARDS:AXIN1 REACTOME:50579 KEGG:8312 ATLASONC:AXIN1ID379ch16p13 WIKI:AXIN1
axin 2
HUGO:AXIN2 HGNC:904 ENTREZ:8313 UNIPROT:Q9Y2T1 GENECARDS:AXIN2 KEGG:8313 ATLASONC:AXIN2ID456ch17q24 WIKI:AXIN2

Maps_Modules
HMC:SUSTAINING_PROLIFERATIVE_SIGNALLING
 Cell Cycle DNA Repair  map  / M_CC_PHASE  map
HMC:RESISTING_CELL_DEATH
HMC:DEREGULATING_CELLULAR_ENERGETICS
 Regulated Cell Death  map  / GLUCOSE_METABOLISM  map
HMC:EVADING_GROWTH_SUPPRESSORS
 Survival  map  / WNT_CANONICAL  map
 Survival  map  / WNT_NON_CANONICAL  map

References
PMID:18590585, PMID:17303408, PMID:17660363, PMID:7575488, PMID:15279786

Modifications:
In compartment: Nucleus
  1. APC2*@Nucleus map
Participates in complexes:
In compartment: Cytoplasm
  1. APC2*:​GSK3*@Cytoplasm map
  2. APC2*:​CK1_epsilon_*:​CTHRC1:​DAAM1:​DVL*|​pho|​S142_pho|​S139_pho:​FZD*:​GSK3*:​PAR6*:​RACK1*:​ROR2|​S864_pho|​pho|​pho:​RSPO3:​SYN4*:​VANGL*|​pho|​pho|​pho|​pho:​WGEF*:​WNT*:​_beta_-Arrestin2*@Cytoplasm map
  3. APC2*:​CK1_epsilon_*:​CTHRC1:​DAAM1:​DVL*|​pho|​S142_pho|​S139_pho:​FZD*:​GSK3*:​PAR6*:​RACK1*:​RHOA:​ROR2|​S864_pho|​pho|​pho:​RSPO3:​SYN4*:​VANGL*|​pho|​pho|​pho|​pho:​WGEF*:​WNT*:​_beta_-Arrestin2*@Cytoplasm map
In compartment: Endosome
  1. APC2*:​CK1_epsilon_*:​CTHRC1:​DVL*|​pho|​S142_pho|​S139_pho:​FZD*:​GSK3*:​PAR6*:​RACK1*:​ROR2|​S864_pho|​pho|​pho:​RSPO3:​SYN4*:​VANGL*:​WNT*:​_beta_-Arrestin2*@Endosome map
  2. APC2*:​CK1_epsilon_*:​CTHRC1:​DVL*|​pho|​S142_pho|​S139_pho:​FZD*:​GSK3*:​PAR6*:​RACK1*:​ROR2|​S864_pho|​pho|​pho:​RSPO3:​SYN4*:​VANGL*|​pho|​pho|​pho|​pho:​WNT*:​_beta_-Arrestin2*@Endosome map
  3. APC2*:​CK1_epsilon_*:​CTHRC1:​DVL*|​pho|​S142_pho|​S139_pho:​FZD*:​GSK3*:​PAR6*:​PRR*:​RACK1*:​ROR2|​S864_pho:​RSPO3:​SYN4*:​VANGL*:​WNT*:​_beta_-Arrestin2*@Endosome map
In compartment: Nucleus
  1. APC1*:​APC10*:​APC11*:​APC12*:​APC2*:​APC3*:​APC4*:​APC5*:​APC6*:​APC7*:​APC8*@Nucleus map
  2. APC1*:​APC10*:​APC11*:​APC12*:​APC2*:​APC3*:​APC4*:​APC5*:​APC6*:​APC7*:​APC8*:​CDC20@Nucleus map
  3. APC1*:​APC10*:​APC11*:​APC12*:​APC2*:​APC3*:​APC4*:​APC5*:​APC6*:​APC7*:​APC8*:​E-Cadherin*@Nucleus map
  4. APC1*:​APC10*:​APC11*:​APC12*:​APC2*:​APC3*:​APC4*:​APC5*:​APC6*:​APC7*:​APC8*:​E-Cadherin*|​pho@Nucleus map
  5. APC1*:​APC10*:​APC11*:​APC12*:​APC2*:​APC3*:​APC4*:​APC5*:​APC6*:​APC7*:​APC8*:​CDC20|​pho:​CyclinA1*@Nucleus map
  6. APC1*:​APC10*:​APC11*:​APC12*:​APC2*:​APC3*:​APC4*:​APC5*:​APC6*:​APC7*:​APC8*:​BUB1|​pho:​BUB3:​BUBR1*:​CDC20:​MAD1*|​pho:​MAD2*@Nucleus map
Participates in reactions:
As Reactant or Product:
  1. E-Cadherin*@Nucleus map + APC1*:​APC10*:​APC11*:​APC12*:​APC2*:​APC3*:​APC4*:​APC5*:​APC6*:​APC7*:​APC8*@Nucleus map → map APC1*:​APC10*:​APC11*:​APC12*:​APC2*:​APC3*:​APC4*:​APC5*:​APC6*:​APC7*:​APC8*:​E-Cadherin*@Nucleus map
  2. APC1*:​APC10*:​APC11*:​APC12*:​APC2*:​APC3*:​APC4*:​APC5*:​APC6*:​APC7*:​APC8*@Nucleus map + CDC20@Nucleus map → map APC1*:​APC10*:​APC11*:​APC12*:​APC2*:​APC3*:​APC4*:​APC5*:​APC6*:​APC7*:​APC8*:​CDC20@Nucleus map
  3. APC1*:​APC10*:​APC11*:​APC12*:​APC2*:​APC3*:​APC4*:​APC5*:​APC6*:​APC7*:​APC8*:​E-Cadherin*@Nucleus map → map APC1*:​APC10*:​APC11*:​APC12*:​APC2*:​APC3*:​APC4*:​APC5*:​APC6*:​APC7*:​APC8*:​E-Cadherin*|​pho@Nucleus map
  4. APC1*:​APC10*:​APC11*:​APC12*:​APC2*:​APC3*:​APC4*:​APC5*:​APC6*:​APC7*:​APC8*:​E-Cadherin*|​pho@Nucleus map → map APC1*:​APC10*:​APC11*:​APC12*:​APC2*:​APC3*:​APC4*:​APC5*:​APC6*:​APC7*:​APC8*:​E-Cadherin*@Nucleus map
  5. APC1*:​APC10*:​APC11*:​APC12*:​APC2*:​APC3*:​APC4*:​APC5*:​APC6*:​APC7*:​APC8*:​CDC20@Nucleus map → map APC1*:​APC10*:​APC11*:​APC12*:​APC2*:​APC3*:​APC4*:​APC5*:​APC6*:​APC7*:​APC8*:​CDC20|​pho:​CyclinA1*@Nucleus map
  6. APC1*:​APC10*:​APC11*:​APC12*:​APC2*:​APC3*:​APC4*:​APC5*:​APC6*:​APC7*:​APC8*:​CDC20|​pho:​CyclinA1*@Nucleus map → map APC1*:​APC10*:​APC11*:​APC12*:​APC2*:​APC3*:​APC4*:​APC5*:​APC6*:​APC7*:​APC8*:​CDC20@Nucleus map
  7. APC1*:​APC10*:​APC11*:​APC12*:​APC2*:​APC3*:​APC4*:​APC5*:​APC6*:​APC7*:​APC8*:​E-Cadherin*@Nucleus map → map E-Cadherin*@Nucleus map + APC1*:​APC10*:​APC11*:​APC12*:​APC2*:​APC3*:​APC4*:​APC5*:​APC6*:​APC7*:​APC8*@Nucleus map
  8. APC1*:​APC10*:​APC11*:​APC12*:​APC2*:​APC3*:​APC4*:​APC5*:​APC6*:​APC7*:​APC8*:​CDC20@Nucleus map → map APC1*:​APC10*:​APC11*:​APC12*:​APC2*:​APC3*:​APC4*:​APC5*:​APC6*:​APC7*:​APC8*@Nucleus map + CDC20@Nucleus map
  9. APC1*:​APC10*:​APC11*:​APC12*:​APC2*:​APC3*:​APC4*:​APC5*:​APC6*:​APC7*:​APC8*:​CDC20@Nucleus map + MAD2*@Nucleus map + BUBR1*@Nucleus map + BUB3@Nucleus map + MAD1*|​pho@Nucleus map + BUB1|​pho@Nucleus map → map APC1*:​APC10*:​APC11*:​APC12*:​APC2*:​APC3*:​APC4*:​APC5*:​APC6*:​APC7*:​APC8*:​BUB1|​pho:​BUB3:​BUBR1*:​CDC20:​MAD1*|​pho:​MAD2*@Nucleus map
  10. APC1*@Nucleus map + APC2*@Nucleus map + APC3*@Nucleus map + APC4*@Nucleus map + APC5*@Nucleus map + APC6*@Nucleus map + APC7*@Nucleus map + APC8*@Nucleus map + APC10*@Nucleus map + APC11*@Nucleus map + APC12*@Nucleus map → map APC1*:​APC10*:​APC11*:​APC12*:​APC2*:​APC3*:​APC4*:​APC5*:​APC6*:​APC7*:​APC8*@Nucleus map
  11. APC1*:​APC10*:​APC11*:​APC12*:​APC2*:​APC3*:​APC4*:​APC5*:​APC6*:​APC7*:​APC8*:​BUB1|​pho:​BUB3:​BUBR1*:​CDC20:​MAD1*|​pho:​MAD2*@Nucleus map → map APC1*:​APC10*:​APC11*:​APC12*:​APC2*:​APC3*:​APC4*:​APC5*:​APC6*:​APC7*:​APC8*:​CDC20@Nucleus map + BUB3@Nucleus map + BUBR1*@Nucleus map + MAD2*@Nucleus map + MAD1*|​pho@Nucleus map + BUB1|​pho@Nucleus map
  12. APC1*:​APC10*:​APC11*:​APC12*:​APC2*:​APC3*:​APC4*:​APC5*:​APC6*:​APC7*:​APC8*:​E-Cadherin*@Nucleus map → map M phase exit@Nucleus map
  13. APC2*:​GSK3*@Cytoplasm map + CK1_epsilon_*:​CTHRC1:​DVL*|​pho|​S142_pho|​S139_pho:​FZD*:​PAR6*:​PRR*:​RACK1*:​ROR2:​RSPO3:​SYN4*:​VANGL*:​WNT*:​_beta_-Arrestin2*@Endosome map → map APC2*:​CK1_epsilon_*:​CTHRC1:​DVL*|​pho|​S142_pho|​S139_pho:​FZD*:​GSK3*:​PAR6*:​PRR*:​RACK1*:​ROR2|​S864_pho:​RSPO3:​SYN4*:​VANGL*:​WNT*:​_beta_-Arrestin2*@Endosome map
  14. APC2*:​CK1_epsilon_*:​CTHRC1:​DVL*|​pho|​S142_pho|​S139_pho:​FZD*:​GSK3*:​PAR6*:​RACK1*:​ROR2|​S864_pho|​pho|​pho:​RSPO3:​SYN4*:​VANGL*|​pho|​pho|​pho|​pho:​WNT*:​_beta_-Arrestin2*@Endosome map + WGEF*@Cytoplasm map + DAAM1@Cytoplasm map + RHOA@Cytoplasm map → map APC2*:​CK1_epsilon_*:​CTHRC1:​DAAM1:​DVL*|​pho|​S142_pho|​S139_pho:​FZD*:​GSK3*:​PAR6*:​RACK1*:​RHOA:​ROR2|​S864_pho|​pho|​pho:​RSPO3:​SYN4*:​VANGL*|​pho|​pho|​pho|​pho:​WGEF*:​WNT*:​_beta_-Arrestin2*@Cytoplasm map
  15. APC2*:​CK1_epsilon_*:​CTHRC1:​DAAM1:​DVL*|​pho|​S142_pho|​S139_pho:​FZD*:​GSK3*:​PAR6*:​RACK1*:​ROR2|​S864_pho|​pho|​pho:​RSPO3:​SYN4*:​VANGL*|​pho|​pho|​pho|​pho:​WGEF*:​WNT*:​_beta_-Arrestin2*@Cytoplasm map → map Angiogenesis@Nucleus map
  16. APC2*:​CK1_epsilon_*:​CTHRC1:​DAAM1:​DVL*|​pho|​S142_pho|​S139_pho:​FZD*:​GSK3*:​PAR6*:​RACK1*:​RHOA:​ROR2|​S864_pho|​pho|​pho:​RSPO3:​SYN4*:​VANGL*|​pho|​pho|​pho|​pho:​WGEF*:​WNT*:​_beta_-Arrestin2*@Cytoplasm map → map APC2*:​CK1_epsilon_*:​CTHRC1:​DAAM1:​DVL*|​pho|​S142_pho|​S139_pho:​FZD*:​GSK3*:​PAR6*:​RACK1*:​ROR2|​S864_pho|​pho|​pho:​RSPO3:​SYN4*:​VANGL*|​pho|​pho|​pho|​pho:​WGEF*:​WNT*:​_beta_-Arrestin2*@Cytoplasm map + RHOA@Cytoplasm map
  17. APC2*:​CK1_epsilon_*:​CTHRC1:​DVL*|​pho|​S142_pho|​S139_pho:​FZD*:​GSK3*:​PAR6*:​PRR*:​RACK1*:​ROR2|​S864_pho:​RSPO3:​SYN4*:​VANGL*:​WNT*:​_beta_-Arrestin2*@Endosome map → map WNT canonical pathway@Cytoplasm map
  18. APC2*:​CK1_epsilon_*:​CTHRC1:​DVL*|​pho|​S142_pho|​S139_pho:​FZD*:​GSK3*:​PAR6*:​PRR*:​RACK1*:​ROR2|​S864_pho:​RSPO3:​SYN4*:​VANGL*:​WNT*:​_beta_-Arrestin2*@Endosome map → map APC2*:​CK1_epsilon_*:​CTHRC1:​DVL*|​pho|​S142_pho|​S139_pho:​FZD*:​GSK3*:​PAR6*:​RACK1*:​ROR2|​S864_pho|​pho|​pho:​RSPO3:​SYN4*:​VANGL*:​WNT*:​_beta_-Arrestin2*@Endosome map
  19. APC2*:​CK1_epsilon_*:​CTHRC1:​DVL*|​pho|​S142_pho|​S139_pho:​FZD*:​GSK3*:​PAR6*:​RACK1*:​ROR2|​S864_pho|​pho|​pho:​RSPO3:​SYN4*:​VANGL*:​WNT*:​_beta_-Arrestin2*@Endosome map → map APC2*:​CK1_epsilon_*:​CTHRC1:​DVL*|​pho|​S142_pho|​S139_pho:​FZD*:​GSK3*:​PAR6*:​RACK1*:​ROR2|​S864_pho|​pho|​pho:​RSPO3:​SYN4*:​VANGL*|​pho|​pho|​pho|​pho:​WNT*:​_beta_-Arrestin2*@Endosome map
As Catalyser:
  1. M phase@Nucleus map → map G1 phase@Nucleus map
  2. CyclinA1*@Nucleus map → map degraded
  3. CyclinB1*@Nucleus map → map degraded
  4. CDC25A@Nucleus map → map degraded
  5. Securin*|​S165_pho@Nucleus map → map degraded
  6. Securin*:​Separin*@Nucleus map → map Securin*@Nucleus map + Separin*@Nucleus map
  7. Separin*@Nucleus map + Securin*@Nucleus map → map Securin*:​Separin*@Nucleus map
  8. SCC1*@Nucleus map + STAG*@Nucleus map + SMC3@Nucleus map + SMC1*@Nucleus map → map SCC1*:​SMC1*:​SMC3:​STAG*@Nucleus map
  9. SCC1*:​SMC1*:​SMC3:​STAG*@Nucleus map → map STAG*@Nucleus map + SCC1*@Nucleus map + SMC3@Nucleus map + SMC1*@Nucleus map
  10. APC2*:​CK1_epsilon_*:​CTHRC1:​DVL*|​pho|​S142_pho|​S139_pho:​FZD*:​GSK3*:​PAR6*:​PRR*:​RACK1*:​ROR2|​S864_pho:​RSPO3:​SYN4*:​VANGL*:​WNT*:​_beta_-Arrestin2*@Endosome map → map APC2*:​CK1_epsilon_*:​CTHRC1:​DVL*|​pho|​S142_pho|​S139_pho:​FZD*:​GSK3*:​PAR6*:​RACK1*:​ROR2|​S864_pho|​pho|​pho:​RSPO3:​SYN4*:​VANGL*:​WNT*:​_beta_-Arrestin2*@Endosome map