Identifiers
calcium/calmodulin-dependent serine protein kinase (MAGUK family)
HUGO:CASK, HGNC:1497, ENTREZ:8573, UNIPROT:O14936, GENECARDS:GC0XM041374????
Maps_Modules
HMC:ACTIVATING_INVASION_AND_METASTASIS
EMT Senescence / EMT_REGULATORS
EMT Senescence / CYTOSKELETON_POLARITY
References
PMID:9753323
Heterotrimeric complex Lin2-Lin7-Lin10 (C. elegans)
PMID:9822620
human lin10 contains 2 PDZ domains
human lin10 interacts with mammalian lin2 (CASK)
mammalian lin7 interacts with mammalian lin2 (CASK)
heterotrimeric complex Lin2-lin7-Lin10 in mouse brain
PMID:9753324
Trimeric complex Lin2-Lin7-Lin10 in brain.
Each protein contains PDZ domains-not involved in complex formation
PMID:10871881
LIN2(CASK) contains two L27 domains, 1 PDZ domain, 1 SH3 domain, 1 inactive Guanylate Kinase domain
LIN7 contains one L27 domain, 1 PDZ domain
Interaction LIN2-LIN7 via L27 domain
Maps_Modules
HMC:ACTIVATING_INVASION_AND_METASTASIS
EMT Senescence / EMT_REGULATORS
EMT Senescence / CYTOSKELETON_POLARITY
References
PMID:9753323
Heterotrimeric complex Lin2-Lin7-Lin10 (C. elegans)
PMID:9822620
human lin10 contains 2 PDZ domains
human lin10 interacts with mammalian lin2 (CASK)
mammalian lin7 interacts with mammalian lin2 (CASK)
heterotrimeric complex Lin2-lin7-Lin10 in mouse brain
PMID:9753324
Trimeric complex Lin2-Lin7-Lin10 in brain.
Each protein contains PDZ domains-not involved in complex formation
PMID:10871881
LIN2(CASK) contains two L27 domains, 1 PDZ domain, 1 SH3 domain, 1 inactive Guanylate Kinase domain
LIN7 contains one L27 domain, 1 PDZ domain
Interaction LIN2-LIN7 via L27 domain
em_emtc_emtc_re32( EMT Senescence ):
PMID:17486063
ZEB1 represses PATJ* expression
PMID:17012742
Knock down of LIN7 results in loss of expression of PATJ*