Protein VHL
Identifiers
von Hippel-Lindau tumor suppressor, E3 ubiquitin protein ligase
HUGO:VHL HGNC:12687 ENTREZ:7428 UNIPROT:P40337
Maps_Modules
HMC:RESISTING_CELL_DEATH
Regulated Cell Death
/ ANTIOXIDANT_RESPONSE
Modifications:
Participates in complexes:
In compartment: Cytosol
- 2-oxoglutarate:CUL2:O_sub_2_endsub_:RACK1*:RBX1:TCEB1:TCEB2:VHL@Cytosol
Participates in reactions:
As Reactant or Product:- HIF1A@Cytosol
+ 2-oxoglutarate:CUL2:O_sub_2_endsub_:RACK1*:RBX1:TCEB1:TCEB2:VHL@Cytosol
+ 2-oxoglutarate:CUL2:O_sub_2_endsub_:RACK1*:RBX1:TCEB1:TCEB2:VHL@Cytosol
→
HIF1A|P564_hyd@Cytosol
+ succinate@Cytosol
+ CO_sub_2_endsub_@Cytosol
As Catalyser:- HIF1A|P564_hyd@Cytosol
→
HIF1A|ubi|P564_hyd@Cytosol