Catalysis

1. ITCH|​unk@Cytosol

References
PMID:20068034
in H1299, ITCH downregulates the expression of TXNIP (siRNA against ITCH, ITCH ectopic expression), ITCH interacts with TXNIP and promotes its ubiquitinylation
in vitro, in H1299, reconstitution of the ubiquitin-ligase system