Identifiers
thioredoxin interacting protein
HUGO:TXNIP HGNC:16952 ENTREZ:10628 UNIPROT:Q9H3M7
Maps_Modules
HMC:RESISTING_CELL_DEATH
HMC:DEREGULATING_CELLULAR_ENERGETICS
Regulated Cell Death / ANTIOXIDANT_RESPONSE
Regulated Cell Death / GLUCOSE_METABOLISM
Maps_Modules
HMC:RESISTING_CELL_DEATH
HMC:DEREGULATING_CELLULAR_ENERGETICS
Regulated Cell Death / ANTIOXIDANT_RESPONSE
Regulated Cell Death / GLUCOSE_METABOLISM
References
rc_re274( Regulated Cell Death ):
PMID:17472435
in human adipocytes and skeletal muscle cells differentiated in vitro, using RNA interference to TXNIP
PMID:18458340
in HA1ER cells (human embryonic kidney epithelial cells,express hTERT, the early region from simian virus 40, and HA H-RasG12V), knock-down of MondoA induces reduced expression of TXNIP and increased glucose uptake, which is reversed by ectopic expression of TXNIP
rc_re1134( Regulated Cell Death ):
PMID:17603038
in HLE B3 human lens epithelial cells, TXNIP interacts with TXN and its over-expression decreases TXN disulfide reductase activity
PMID:19847012
in HEK293, upon TXNIP ectopic expression, suppression of TXN denitrosylase activity
PMID:17976314
review
rc_re1135( Regulated Cell Death ):
PMID:20068034
in H1299, ITCH downregulates the expression of TXNIP (siRNA against ITCH, ITCH ectopic expression), ITCH interacts with TXNIP and promotes its ubiquitinylation
in vitro, in H1299, reconstitution of the ubiquitin-ligase system
Maps_Modules
HMC:RESISTING_CELL_DEATH
HMC:DEREGULATING_CELLULAR_ENERGETICS
Regulated Cell Death / ANTIOXIDANT_RESPONSE
Regulated Cell Death / GLUCOSE_METABOLISM
References
rc_re1135( Regulated Cell Death ):
PMID:20068034
in H1299, ITCH downregulates the expression of TXNIP (siRNA against ITCH, ITCH ectopic expression), ITCH interacts with TXNIP and promotes its ubiquitinylation
in vitro, in H1299, reconstitution of the ubiquitin-ligase system