Identifiers
tumor protein p73
HUGO:TP73, HGNC:12003, ENTREZ:7161, UNIPROT:Q8TDY6
HUGO:TP73 HGNC:12003 ENTREZ:7161 UNIPROT:O15350
Maps_Modules
HMC:SUSTAINING_PROLIFERATIVE_SIGNALLING
Cell Cycle DNA Repair / G2_M_CHECKPOINT
HMC:RESISTING_CELL_DEATH
Regulated Cell Death / APOPTOSIS
Regulated Cell Death / RCD_GENES
References
PMID:12890487, PMID:10362363, PMID:20485546, PMID:18260640, PMID:21317061, PMID:21672615, PMID:21516125
References
ce_re54:( Cell Cycle DNA Repair ) PMID:19788416
References
ce_re54:( Cell Cycle DNA Repair ) PMID:19788416
ce_re120( Cell Cycle DNA Repair ):
By CycB*/CDC2*:
G2/M transition
PMID:16818604
For BRCA2 and FANCD2/FANCDI importance in the cytokinesis and localisation at the spindle and role in the propagation of mitosis:
PMID:15375219, PMID:19686080
CDC2 has to be phosphorylated fot inhibition of G2 to M propagation (called G2 checkpoint). FANCC activates CDC2 phosphorylation
PMID:15377654
Brca1 ubiquitinates CtIp and in complex they inhibit G2 to M propagation (G2 checkpoint)
PMID:16818604, PMID:15485915
BRCA1 and FANCJ in complex inhibit G2 to M propagation (called G2 checkpoint).
PMID:15242590
FANCM:FAAP24 complex activated G2 phase checpoint (G2 to M propagation inhibition):
PMID:18995830
ATR kinase activation mediated by MutSalpha and MutLalpha in response to cytotoxic O6-methylguanine adducts. O6-methylguanine adducts recognized by MutSalpha, MutLalpha and BER pathways performs the repair:
PMID:16713580, PMID:18543256
BER and MMR interaction and G2/M arrest inresponce to o6-meG formation:
PMID:14614141
Maps_Modules
HMC:RESISTING_CELL_DEATH
Regulated Cell Death / APOPTOSIS
Regulated Cell Death / RCD_GENES
References
rc_re525( Regulated Cell Death ):
PMID:19581926
in vitro, SCF FBXO45 complex ubiquitinates TP73
in SH-5YSY neuroblastoma cells, FBXO45 mediates proteasome dependent degradation of TP73