Reaction state_transition su_mpk1_mpk1_re262 map

FOXO3@Cytoplasm map → FOXO3|​pho@Nucleus map

Reaction regulators:
Catalysis
  1. MST1|​pho@Nucleus map
Inhibition
  1. AKT*|​pho@Cytoplasm map


References
JNK phosphorylates MST1 at serine 82 which leads to the enhancement of MST1 activation. The activation of MST1 phosphorylates FOXO3 at serine 207 and promotes cell death.
Phosphorylation of FOXO3 by Akt creates a binding site for the 14-3-3 family of proteins. The complex of FOXO3 and 14-3-3 is retained in the cytosol blocking transcription of genes normally stimulated by FOXO3.
PMID:20028971 PMID:12040186