Identifiers
death-associated protein kinase 1
HUGO:DAPK1 HGNC:2674 ENTREZ:1612 UNIPROT:P53355

Maps_Modules
HMC:RESISTING_CELL_DEATH
 Regulated Cell Death   / STARVATION_AUTOPHAGY 
 Regulated Cell Death   / DEATH_RECEPTOR_PATHWAYS 
 Regulated Cell Death   / DEPENDANCE_RECEPTORS 

References
PMID:17703233
DAP kinase regulates JNK signaling by binding and activating protein kinase D

Maps_Modules
HMC:RESISTING_CELL_DEATH
 Regulated Cell Death   / STARVATION_AUTOPHAGY 
 Regulated Cell Death   / DEATH_RECEPTOR_PATHWAYS 
 Regulated Cell Death   / DEPENDANCE_RECEPTORS 

References
rc_re362:( Regulated Cell Death  ) PMID:18974095

Maps_Modules
HMC:RESISTING_CELL_DEATH
 Regulated Cell Death   / STARVATION_AUTOPHAGY 
 Regulated Cell Death   / DEATH_RECEPTOR_PATHWAYS 
 Regulated Cell Death   / DEPENDANCE_RECEPTORS 

References
rc_re362:( Regulated Cell Death  ) PMID:18974095
rc_re361( Regulated Cell Death  ):
PMID:18974095
in HEK293, in vitro
by DAPK1 (DAPK1 phosphorylation status not assessed)
rc_re1032( Regulated Cell Death  ):
PMID:19180116
PMID:11323415
in HEK293
in vitro
DAPK1 mediated phosphorylation of BECN1 promotes dissociation of beclin 1 from Bcl-XL and induction of autophagy

1. DAPK1|​emp@Cytosol
2. DAPK1|​S289_pho@Cytosol

1. DAPK1|​emp:​UNC5B-DD*@Cytosol
2. CIP2A*:​DAPK1|​pho:​NTN1:​UNC5B@Cytosol
3. DAPK1|​emp:​PPP2CB:​PPPR1B:​UNC5B@Cytosol

1. CIP2A*:​DAPK1|​pho:​NTN1:​UNC5B@Cytosol + PPP2CB:​PPPR1B@Cytosol → NTN1@Extracellular space + DAPK1|​emp:​PPP2CB:​PPPR1B:​UNC5B@Cytosol + CIP2A*@Cytosol
2. DAPK1|​emp:​PPP2CB:​PPPR1B:​UNC5B@Cytosol → cleaved UNC5B*@Cytosol + DAPK1|​emp:​UNC5B-DD*@Cytosol
3. DAPK1|​emp@Cytosol → DAPK1|​S289_pho@Cytosol

1. BECN1@Cytosol → BECN1|​T119_pho@Cytosol
2. PRKD1@Cytosol → PRKD1|​pho|​active@Cytosol
3. TSC1:​TSC2|​M1_unk@Cytosol → TSC1@Cytosol + TSC2|​pho|​M1_unk@Cytosol