Identifiers
NAME:CIP2A*:DAPK1:NTN1:UNC5B
References
PMID:19543238
PMID:21172653
UNC5H2/B recruits a protein complex that includes PR65?? and DAPk and retains PP2A activity. PP2A activity is required for UNC5H2/B-induced apoptosis, since it activates DAPk by triggering its dephosphorylation. Moreover, netrin-1 binding to UNC5H2/B prevents this effect through interaction of the PP2A inhibitor CIP2A to UNC5H2/B
PMID:12598906
p53RDL1 interacted with its ligand, Netrin-1, p53-dependent apoptosis was blocked
rc_re1693( Regulated Cell Death ):
The UNC5H dependence receptors promote apoptosis in the absence of their ligand, netrin-1
in the absence of netrin-1, recruitment of PP2A to UNC5H2/B allows the activation of DAPk via a PP2A-mediated dephosphorylation
+ PPP2CB:PPPR1B@Cytosol → NTN1@Extracellular space + DAPK1|emp:PPP2CB:PPPR1B:UNC5B@Cytosol + CIP2A*@Cytosol