Complex DAPK1:PPP2CB:PPPR1B:UNC5B map
Complex composition:

  1. DAPK1 map
  2. PPPR1B map
  3. PPP2CB map
  4. UNC5B map

DAPK1|​emp:​PPP2CB:​PPPR1B:​UNC5B@Cytosol

Identifiers
NAME:DAPK1:PPP2CB:PPPR1B:UNC5B

References
PMID:21172653
in the absence of netrin-1, recruitment of PP2A to UNC5H2/B allows the activation of DAPk via a PP2A-mediated dephosphorylation
PMID:21172648
rc_re1693( Regulated Cell Death  map ):
PMID:19543238
The UNC5H dependence receptors promote apoptosis in the absence of their ligand, netrin-1
rc_re1696( Regulated Cell Death  map ):
in the absence of ligand, the intracellular domain of monomeric UNC5B undergoes cleavage and conformational changes that enable binding of the PR65b subunit of PP2A. This drives dephosphorylation and activation of DAPK, thereby inducing proapoptotic signaling

Modifications:
Participates in complexes:
In compartment: Cytosol
  1. DAPK1|​emp:​PPP2CB:​PPPR1B:​UNC5B@Cytosol map
Participates in reactions:
As Reactant or Product:
  1. CIP2A*:​DAPK1|​pho:​NTN1:​UNC5B@Cytosol map + PPP2CB:​PPPR1B@Cytosol map → map NTN1@Extracellular space map + DAPK1|​emp:​PPP2CB:​PPPR1B:​UNC5B@Cytosol map + CIP2A*@Cytosol map
  2. DAPK1|​emp:​PPP2CB:​PPPR1B:​UNC5B@Cytosol map → map cleaved UNC5B*@Cytosol map + DAPK1|​emp:​UNC5B-DD*@Cytosol map
As Catalyser: