Protein cleaved UNC5B* map

Identifiers
unc-5 homolog B (C. elegans)
HUGO:UNC5B HGNC:12568 ENTREZ:219699 UNIPROT:Q8IZJ1

Maps_Modules
HMC:RESISTING_CELL_DEATH
 Regulated Cell Death  map  / DEATH_RECEPTOR_PATHWAYS  map
 Regulated Cell Death  map  / DEPENDANCE_RECEPTORS  map

References
PMID:11387206
PMID:18582460
PMID:21172648
in the absence of ligand, the intracellular domain of monomeric UNC5B undergoes cleavage

cleaved UNC5B*@Cytosol

Maps_Modules
HMC:RESISTING_CELL_DEATH
 Regulated Cell Death  map  / DEATH_RECEPTOR_PATHWAYS  map
 Regulated Cell Death  map  / DEPENDANCE_RECEPTORS  map

References
rc_re1696( Regulated Cell Death  map ):
PMID:21172648
in the absence of ligand, the intracellular domain of monomeric UNC5B undergoes cleavage and conformational changes that enable binding of the PR65b subunit of PP2A. This drives dephosphorylation and activation of DAPK, thereby inducing proapoptotic signaling

Modifications:
In compartment: Cytosol
  1. cleaved UNC5B*@Cytosol map
Participates in complexes:
    Participates in reactions:
    As Reactant or Product:
    1. DAPK1|​emp:​PPP2CB:​PPPR1B:​UNC5B@Cytosol map → map cleaved UNC5B*@Cytosol map + DAPK1|​emp:​UNC5B-DD*@Cytosol map
    As Catalyser: