Identifiers
GJA3_8_GJB1_GJB2*
gap junction protein, beta 1, 32kDa
HUGO:GJB1, HGNC:4283, ENTREZ:2705, UNIPROT:P08034, GENECARDS:GC0XP070435
gap junction protein, alpha 3, 46kDa
HUGO:GJA3, HGNC:4277, ENTREZ:2700 , UNIPROT:Q9Y6H8, GENECARDS:GC13M020712 ??
gap junction protein, alpha 8, 50kDa
HUGO:GJA8, HGNC:4281, ENTREZ:2703, UNIPROT:P48165, GENECARDS:GC01P147374
gap junction protein, beta 2, 26kDa
HUGO:GJB2, HGNC:4284, ENTREZ:2706, UNIPROT:P29033, GENECARDS:GC13M020761
Maps_Modules
HMC:ACTIVATING_INVASION_AND_METASTASIS
EMT Senescence / EMT_REGULATORS
EMT Senescence / CELL_CELL_ADHESIONS
EMT Senescence / GAP_JUNCTIONS
References
GJB1 is so-called Connexin 32 or Cx32
PMID:9592087
Cx32 (GJB1) interacts with Cx26(GJB2), Cx46(GJA3), and Cx50(GJA8) but failing to do so with Cx40(GJA5).
PMID:15782139
Cx32 has a strong tumor-suppressive effect on a human metastatic renal cell carcinoma cell line.
Cx32-dependent inactivation of Src decreased the production of VEGF via the suppression of Stat3 activation
References
em_emtc_emtc_re534( EMT Senescence ):
GJB1 is so-called Connexin 32 or Cx32
PMID:9592087
Cx32 (GJB1) interacts with Cx26(GJB2), Cx46(GJA3), and Cx50(GJA8) but failing to do so with Cx40(GJA5).
+ GJB1@Cytosol → GJA3_8_GJB1_GJB2*:GJB1@Neighbouring Cell
→ GJA3@Neighbouring Cell
→ GJA8@Neighbouring Cell
→ GJB1@Neighbouring Cell
→ GJB2@Neighbouring Cell
→ Gap junctions@Cytosol