Phenotype Gap junctions map
Gap junctions@Cytosol

Maps_Modules
HMC:ACTIVATING_INVASION_AND_METASTASIS
 EMT Senescence  map  / EMT_REGULATORS  map
 EMT Senescence  map  / CYTOSKELETON_POLARITY  map
 EMT Senescence  map  / CELL_CELL_ADHESIONS  map
 EMT Senescence  map  / CELL_MATRIX_ADHESIONS  map
 EMT Senescence  map  / ECM  map
 EMT Senescence  map  / TIGHT_JUNCTIONS  map
 EMT Senescence  map  / GAP_JUNCTIONS  map
 EMT Senescence  map  / ADHERENS_JUNCTIONS  map
 EMT Senescence  map  / DESMOSOMES  map

References
em_emtc_emtc_re665( EMT Senescence  map ):
PMID:11557048
The growing number of connexins (i.e. Cx43 and Cx45) that can associate with ZO proteins indicate that ZO proteins may play a more general role in organizing gap junctions and/or in recruiting signaling molecules that regulate intercellular communication.
em_emtc_emtc_re666( EMT Senescence  map ):
PMID:12808044
Cx46 (GJA3) and Cx50 (GJA8) interact with ZO-1
PMID:21965293
Cx50 requires an intact PDZ-binding motif and ZO-1 for the formation of functional intercellular channels.
PMID:19439604
ZO-1 formed a clear margin around the large Cx50 plaques instead of being colocalized with the connexin staining.
This finding suggests the involvement of ZO-1 in the composition of tight or adherens junctions around gap-junctional plaques instead of interacting with connexins directly

Modifications:
In compartment: Cytosol
  1. Gap junctions@Cytosol map
Participates in complexes:
    Participates in reactions:
    As Reactant or Product:
    1. em_emtc_emtc_s2873 → map Gap junctions@Cytosol map
    2. em_emtc_emtc_s2868 → map Gap junctions@Cytosol map
    3. EMT@Cytosol map → map Gap junctions@Cytosol map
    4. GJA1:​GJA1_4_GJC1*@Neighbouring Cell map → map Gap junctions@Cytosol map
    5. GJA1_3_4_8_GJB2*:​GJA3@Neighbouring Cell map → map Gap junctions@Cytosol map
    6. em_emtc_emtc_s2474 → map Gap junctions@Cytosol map
    7. GJA1_5_GJC1*:​GJA5@Neighbouring Cell map → map Gap junctions@Cytosol map
    8. em_emtc_emtc_s2484 → map Gap junctions@Cytosol map
    9. GJA3_8_GJB1_GJB2*:​GJB1@Neighbouring Cell map → map Gap junctions@Cytosol map
    10. ZO1_3*@Cytosol map → map Gap junctions@Cytosol map
    11. GJA3_8*:​ZO1*@Cytosol map → map Gap junctions@Cytosol map
    12. Gap junctions@Cytosol map → map Cell-cell adhesions@Neighbouring Cell map
    As Catalyser: