Identifiers
NAME:GJA3_8_GJB1_GJB2*:GJB1
Maps_Modules
HMC:ACTIVATING_INVASION_AND_METASTASIS
EMT Senescence
/ EMT_REGULATORS
EMT Senescence
/ CELL_CELL_ADHESIONS
EMT Senescence
/ GAP_JUNCTIONS
References
GJB1 is so-called Connexin 32 or Cx32
PMID:9592087
Cx32 (GJB1) interacts with Cx26(GJB2), Cx46(GJA3), and Cx50(GJA8) but failing to do so with Cx40(GJA5).
PMID:15782139
Cx32 has a strong tumor-suppressive effect on a human metastatic renal cell carcinoma cell line.
Cx32-dependent inactivation of Src decreased the production of VEGF via the suppression of Stat3 activation