Identifiers
integrin linked kinase
HUGO:ILK hgnc_id:HGNC:6040 HGNC:6040 ENTREZ:3611 UNIPROT:Q13418
References
CASCADE:INTEGRIN
PMID:11696562
Integrin-linked kinase (ILK) is a binding partner of the integrin 1 and 3 subunits and is involved in the signal transduction from integrin receptors
The activity is stimulated in a phosphatidylinositol (PI) 3-kinase???dependent manner and likely involves binding of the phosphoinositide phospholipid product of PI 3-kinase, PI 3,4,5-triphosphate, to the PH-like domain of ILK
ILK has been shown recently to directly phosphorylate proteins such as PKB (PKB/Akt) on ser 473.
PMID:15905178
Knock-down of ILK by small, interfering RNA (siRNA) attenuated Akt phosphorylation in response to ligation of beta1 integrin by collagen or activating antibody and enhanced fibroblast apoptosis in response to collagen contraction.
PMID:27111285
ILK???PI3K/AKT pathway participates in cutaneous wound contraction by regulating fibroblast migration and differentiation to myofibroblast
PMID:25100717
Probably colagen signaling activates NFkB via ILK
ILK is involved in an alternative activation of NF-??B signaling by modulating the phosphorylation of p65 at Ser-536 (Cre-mediated ILK deletion in ilkfl/fl MEFs demonstrates that LPS-induced p65 Ser-536 phosphorylation was inhibited by ILK deficiency).
PMID:24527345
Integrins are Modulators of Transforming Growth Factor Beta Signaling in Fibroblasts;
integrin-linked kinase-deficient dermal fibroblasts isolated from newborn mice fail to express alpha???smooth muscle actin and to show Smad2 and Smad3 phosphorylation upon stimulation by exogenous TGF-??1.
PMID:25268583
Cross-talk processes between TGF-b and ILK are crucial for
myo???broblast formation, as ILK-de???cient dermal ???broblasts exhibit impaired responses to TGF-b receptor stimulation.
ILK prevents TGFBR2 ubiquitination and degradation.