Identifiers
TIMP metallopeptidase inhibitor 1
HUGO:TIMP1 hgnc_id:HGNC:11820 HGNC:11820 ENTREZ:7076 UNIPROT:P01033
"tissue inhibitor of metalloproteinase 1"
HUGO:TIMP1 HGNC:11820 ENTREZ:7076 UNIPROT:P01033
HUGO:TIMP1

Maps_Modules
HMC:TUMOR_PROMOTING_INFLAMMATION
HMC:ACTIVATING_INVASION_AND_METASTASIS
 Cancer Associated Fibroblasts   / MATRIX_REGULATION 
 EMT Senescence   / EMT_REGULATORS 
 EMT Senescence   / ECM 
 Innate Immunity   / TUMOR_GROWTH 

References
CASCADE:TGFB
CASCADE:IL6
CASCADE:LIF
CASCADE:IL1
PMID:11279127
Dominant-Negative Smad3 and Inhibitory Smad7 Expression Block TGF-??-induced ECM Promoter Activation in fibroblasts
COL1A2, COL3A1, COL6A1, COL6A3, and TIMP-1
 MACROPHAGE 
CASCADE:TLR2_4
PMID:1629188
TIMP1 and TIMP2 are produced by macrophages.
TIMP1 production is upregulated by TLR4 (LPS) TIMP2 production is inhibited by TLR4 signaling.
PMID:24174628
Angiogenic capacity of M1- and M2-polarized macrophages is determined by the levels of TIMP-1 complexed with their secreted proMMP-9

1. TIMP1@Cytosol

1. TIMP1@Extracellular space

1. TIMP1@INNATE_IMMUNE_CELL_Cytosol

1. TIMP1@INNATE_IMMUNE_CELL_Membrane

1. MMP1*:​TIMP1@Extracellular space

1. rTIMP1@Cytosol → TIMP1@Cytosol
2. rTIMP1@Nucleus → TIMP1@Cytosol
3. TIMP1@Cytosol → TIMP1@Extracellular space
4. TIMP family*@Extracellular space → TIMP1@Extracellular space
5. TIMP1@Extracellular space + MMP1*@Extracellular space → MMP1*:​TIMP1@Extracellular space
6. TIMP1@INNATE_IMMUNE_CELL_Membrane → MATRIX_REMODELLING@default
7. TIMP1@INNATE_IMMUNE_CELL_Cytosol → TIMP1@INNATE_IMMUNE_CELL_Membrane