Reaction state_transition ca_re257 map

IRAK1@Cytosol map → IRAK1|​pho|​active@Cytosol map

Reaction regulators:
Catalysis
  1. IL1R1:​IL1RAP:​IRAK4:​MYD88@Cytosol map


References
PMID:12620219
MyD88 mediates a close interaction of the two related IRAK molecules,
which is essential to allow IRAK-4 to phosphorylate IRAK-1. Phosphorylation of IRAK-1
reduces its affinity for MyD88, while increasing its affinity for TRAF6