Protein IL1R1 map

Identifiers
interleukin 1 receptor type 1
HUGO:IL1R1 hgnc_id:HGNC:5993 HGNC:5993 ENTREZ:3554 UNIPROT:P14778
HUGO:IL1R
interleukin 1 receptor type I
IL1R IL1RA
HUGO:IL1R1 HGNC:5993 ENTREZ:3554 UNIPROT:P14778

Maps_Modules
HMC:TUMOR_PROMOTING_INFLAMMATION
HMC:ACTIVATING_INVASION_AND_METASTASIS
 Cancer Associated Fibroblasts  map  / INFLAMMATORY_SIGNALING_PATHWAYS  map
HMC:AVOIDING_IMMUNE_DESTRUCTION
 Innate Immunity  map  / RECRUITMENT_OF_IMMUNE_CELLS  map
HMC:EVADING_GROWTH_SUPPRESSORS
 Survival  map  / MAPK  map

References
CASCADE:IL1
PMID:18977329
IL-1?? activates MDSC in vitro and in vivo through an IL-1RI/NF-??B pathway.
 MDSC  map
IL-1 likely requires TRAF6 to signal to the SAPKs. IL-1 binding to its receptor (IL-1R) triggers heterodimerisation of IL-1R with IL-1RAcP (not modelled) a transmembrane protein necessary for IL-1 signal transduction. The IL-1R/IL-1RAcP heterodimer then recruits the death domain adapter protein MyD88.
PMID:11274345

IL1R1@Plasma Membrane

References
su_mpk1_mpk1_re126( Survival  map ):
The IL-1R/IL-1RAcP heterodimer recruits the death domain adapter protein MyD88.
PMID:11274345

Modifications:
In compartment: Plasma Membrane
  1. IL1R1@Plasma Membrane map
Participates in complexes:
In compartment: Cytoplasm
  1. IL1R1:​IRAK1:​MYD88:​TAK1*|​pho:​TRAF6@Cytoplasm map
In compartment: Cytosol
  1. IL1R1:​IL1RAP@Cytosol map
  2. IL1R1:​IL1RAP:​IRAK4:​MYD88@Cytosol map
In compartment: INNATE_IMMUNE_CELL_Membrane
  1. IL1R1:​IL1RAP@INNATE_IMMUNE_CELL_Membrane map
  2. IL1R1:​IL1RAP:​trILB1@INNATE_IMMUNE_CELL_Membrane map
In compartment: Plasma Membrane
  1. IL1R1:​MYD88@Plasma Membrane map
  2. IL1R1:​IRAK1:​MYD88@Plasma Membrane map
  3. IL1R1:​IRAK1:​MYD88:​TRAF6@Plasma Membrane map
Participates in reactions:
As Reactant or Product:
  1. IL1R1:​IL1RAP@Cytosol map + MYD88@Cytosol map + IRAK4@Cytosol map → map IL1R1:​IL1RAP:​IRAK4:​MYD88@Cytosol map
  2. IL1R1:​IL1RAP:​trILB1@INNATE_IMMUNE_CELL_Membrane map → map RECRUITMENT_OF_IMMUNE_CELLS@INNATE_IMMUNE_CELL_Cytosol map
  3. trILB1@default map + IL1R1:​IL1RAP@INNATE_IMMUNE_CELL_Membrane map → map IL1R1:​IL1RAP:​trILB1@INNATE_IMMUNE_CELL_Membrane map
  4. MYD88@Cytoplasm map + IL1R1@Plasma Membrane map → map IL1R1:​MYD88@Plasma Membrane map
  5. IRAK1@Cytoplasm map + IL1R1:​MYD88@Plasma Membrane map → map IL1R1:​IRAK1:​MYD88@Plasma Membrane map
  6. TRAF6@Cytoplasm map + IL1R1:​IRAK1:​MYD88@Plasma Membrane map → map IL1R1:​IRAK1:​MYD88:​TRAF6@Plasma Membrane map
  7. TAK1*@Cytoplasm map + IL1R1:​IRAK1:​MYD88:​TRAF6@Plasma Membrane map → map IL1R1:​IRAK1:​MYD88:​TAK1*|​pho:​TRAF6@Cytoplasm map
As Catalyser:
  1. IRAK1@Cytosol map → map IRAK1|​pho|​active@Cytosol map
  2. NFkB*@INNATE_IMMUNE_CELL_Cytosol map → map NFkB*@INNATE_IMMUNE_CELL_Cytosol map
  3. MAP2K6@Cytoplasm map → map MAP2K6|​pho|​pho@Cytoplasm map