Complex IL1R1:IL1RAP:IRAK4:MYD88 map
Complex composition:

  1. IRAK4 map
  2. MYD88 map
  3. IL1R1 map
  4. IL1RAP map

IL1R1:​IL1RAP:​IRAK4:​MYD88@Cytosol

Identifiers
NAME:IL1R1:IL1RAP:IRAK4:MYD88

Maps_Modules
HMC:TUMOR_PROMOTING_INFLAMMATION
HMC:ACTIVATING_INVASION_AND_METASTASIS
 Cancer Associated Fibroblasts  map  / INFLAMMATORY_SIGNALING_PATHWAYS  map

References
CASCADE:IL1
PMID:19161412
IL-1 signaling is initiated by the recruitment of MyD88 to the IL-1RI/IL-1RAcP complex.
The recruitment of MyD88 leads to the recruitment of IRAK1 and IRAK4, probably via their death domains. IRAK4 then activates IRAK1, allowing IRAK1 to autophosphorylate.
ca_re257( Cancer Associated Fibroblasts  map ):
PMID:12620219
MyD88 mediates a close interaction of the two related IRAK molecules,
which is essential to allow IRAK-4 to phosphorylate IRAK-1. Phosphorylation of IRAK-1
reduces its affinity for MyD88, while increasing its affinity for TRAF6

Modifications:
Participates in complexes:
In compartment: Cytosol
  1. IL1R1:​IL1RAP:​IRAK4:​MYD88@Cytosol map
Participates in reactions:
As Reactant or Product:
  1. IL1R1:​IL1RAP@Cytosol map + MYD88@Cytosol map + IRAK4@Cytosol map → map IL1R1:​IL1RAP:​IRAK4:​MYD88@Cytosol map
As Catalyser:
  1. IRAK1@Cytosol map → map IRAK1|​pho|​active@Cytosol map